Nakamura Mariko, Yoshimi Akira, Mouri Akihiro, Tokura Tatsuya, Kimura Hiroyuki, Kishi Shinichi, Miyauchi Tomoya, Iwamoto Kunihiro, Ito Mikiko, Sato-Boku Aiji, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro
Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Nagoya, Japan.
Clinical OMICs and Translation Research Center, Meijo University, Nagoya, Japan.
Hum Psychopharmacol. 2022 Mar;37(2):e2818. doi: 10.1002/hup.2818. Epub 2021 Sep 20.
The aim of this study was evaluation of the association between severity of pain and expression of total or ubiquitinated serotonin transporter (SERT) protein in patients with burning mouth syndrome and atypical odontalgia (BMS/AO), who were treated by duloxetine.
Patients with BMS/AO were assessed for severity of pain using the visual analog scale (VAS), and expression of total and ubiquitinated SERT protein in platelets before (baseline) and 12 weeks after duloxetine-treatment.
The expression of total and ubiquitinated SERT protein at baseline in all patients (n = 33) were higher and lower, respectively, compared to those in healthy controls. 12 weeks after duloxetine-treatment, there was no difference in the total SERT protein levels between patients (n = 21) and healthy controls. In the 16 patients who could be measured, mean VAS scores and total SERT protein levels were significantly decreased after the treatment, compared to those at baseline. There was tendency for a positive correlation between total SERT protein levels and VAS scores in these patients.
Our findings indicate that duloxetine relieves pain in association with downregulation of platelet SERT expression in patients with BMS/AO.
本研究旨在评估接受度洛西汀治疗的灼口综合征和非典型牙痛（BMS/AO）患者的疼痛严重程度与血清素转运体（SERT）总蛋白或泛素化蛋白表达之间的关联。
使用视觉模拟量表（VAS）评估BMS/AO患者的疼痛严重程度，并在度洛西汀治疗前（基线）和治疗12周后检测血小板中SERT总蛋白和泛素化蛋白的表达。
与健康对照组相比，所有患者（n = 33）基线时SERT总蛋白和泛素化蛋白的表达分别更高和更低。度洛西汀治疗12周后，患者（n = 21）与健康对照组之间的SERT总蛋白水平无差异。在可测量的16例患者中，治疗后的平均VAS评分和SERT总蛋白水平与基线时相比显著降低。这些患者的SERT总蛋白水平与VAS评分之间存在正相关趋势。
我们的研究结果表明，度洛西汀可通过下调BMS/AO患者血小板SERT表达来缓解疼痛。
