Academic Department of Radiology, Hôpital Pitié-Salpétrière, Assistance Publique des Hôpitaux de Paris, Paris, France.
Sorbonne Universités, GRC n° 5, Oncotype-Uro, Paris, France.
Br J Radiol. 2022 Mar 1;95(1131):20210156. doi: 10.1259/bjr.20210156. Epub 2021 Sep 19.
To evaluate the impact of age on the zonal anatomy of the prostate by MRI using morphometric and textural analysis.
A total of 154 men (mean age: 63 years) who underwent MRI due to a high prostate-specific antigen (PSA) level were included retrospectively. At each MRI examination the following variables were measured: overall dimensions of the prostate (whole gland (WG), transitional zone (TZ), and peripheral zone (PZ)), and thickness of the anterior fibromuscular stroma (AFMS) and the periprostatic venous plexus (PPVP) on weighted images. Identical regions of interest (ROIs) were delineated on the apparent diffusion coefficient (ADC) map on the anterior (horn) and posterior part of the PZ. Textural (TexRAD) parameter differences between TZ and PZ ROIs on weighted images were analyzed by linear regression. Results were correlated with age (distributed into five decades from 22 to 89 years).
Age was positively correlated with PSA level and glandular volumes (WG, TZ, and TZ/WG ratio; < 0.0001) and was negatively correlated with AFSM and PPVP thickness ( < 0.0001). There was a positive correlation between ADC values of the PZ and age ( = 0.003) and between entropy of the TZ and PZ and age ( < 0.001).
Gradual variations in morphologic and textural features of the prostate were observed with age, mainly due to the increase in TZ volume while PZ volume tended to decrease. These modifications resulted in textural changes mainly at the expense of entropy.
Entropy could be relevant for studying the process of aging of the prostate.
通过形态计量学和纹理分析，利用 MRI 评估年龄对前列腺分区解剖结构的影响。
回顾性分析了 154 名因前列腺特异性抗原（PSA）水平升高而接受 MRI 检查的男性（平均年龄：63 岁）。在每次 MRI 检查中，测量了以下变量：前列腺的整体尺寸（整个腺体（WG）、移行区（TZ）和外周区（PZ）），以及前纤维肌肉基质（AFMS）和前列腺周围静脉丛（PPVP）在加权图像上的厚度。在表观扩散系数（ADC）图上，在 PZ 的前（角）部和后部描绘了相同的感兴趣区（ROI）。分析了 TZ 和 PZ ROI 之间在加权图像上的纹理（TexRAD）参数差异，通过线性回归进行分析。结果与年龄（22 至 89 岁分为五个十年）相关。
年龄与 PSA 水平和腺体体积（WG、TZ 和 TZ/WG 比值）呈正相关（<0.0001），与 AFSM 和 PPVP 厚度呈负相关（<0.0001）。PZ 的 ADC 值与年龄呈正相关（=0.003），而 TZ 和 PZ 的熵与年龄呈正相关（<0.001）。
随着年龄的增长，前列腺的形态和纹理特征逐渐发生变化，主要是由于 TZ 体积的增加，而 PZ 体积则趋于减少。这些变化导致了纹理的改变，主要是熵的减少。
熵可能与研究前列腺衰老过程有关。
