T2 弛豫时间预测磁共振引导高强度聚焦超声治疗子宫肌瘤技术效果的可行性。

Feasibility of T2 relaxation time in predicting the technical outcome of MR-guided high-intensity focused ultrasound treatment of uterine fibroids.

机构信息

Department of Medical Physics, Turku University Hospital, Turku, Finland.

Department of Radiology, Turku University Hospital, Turku, Finland.

出版信息

Int J Hyperthermia. 2021;38(1):1384-1393. doi: 10.1080/02656736.2021.1976850.

DOI:10.1080/02656736.2021.1976850

PMID:34542013

Abstract

PURPOSE

The aim of this study was to assess the feasibility of T2 relaxation time in predicting the immediate technical outcome i.e., nonperfused volume ratio (NPVr) of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment of symptomatic uterine fibroids and to compare it with existing T2-weighted imaging methods (Funaki classification and scaled signal intensity, SSI).

MATERIALS AND METHODS

30 patients with 32 uterine fibroids underwent an MRI study including a quantitative T2 relaxation time measurement prior to MRgHIFU treatment. T2 relaxation times were measured with a multi-echo fast imaging-based technique with 16 echoes. The correlation between pretreatment values of the uterine fibroids and treatment outcomes, that is nonperfused volume ratios (NPVr), was assessed with nonparametric statistical measures. T2 relaxation time-based method was compared to existing T2-weighted imaging-based methods using receiver-operating-characteristics (ROC) curve analysis and Chi-square test.

RESULTS

Nonparametric measures of association revealed a statistically significant negative correlation between T2 relaxation time values and NPVr. The T2 relaxation time classification (T2 I, T2 II, and T2 III) resulted in the whole model -value of 0.0019, whereas the Funaki classification resulted in a -value of 0.56. The T2 relaxation time classification (T2 I and T2 II) achieved a whole model of a -value of 0.0024, whereas the SSI classification had a -value of 0.0749.

CONCLUSIONS

A longer T2 relaxation time of the fibroid prior to treatment correlated with a lower NPVr. Based on our results, the T2 relaxation time classifications seem to outperform the Funaki classification and the SSI method.

摘要

目的

本研究旨在评估 T2 弛豫时间预测磁共振引导高强度聚焦超声（MRgHIFU）治疗症状性子宫肌瘤即刻技术结果（即无灌注体积比[NPVr]）的可行性，并将其与现有的 T2 加权成像方法（Funaki 分类和标化信号强度[SSI]）进行比较。

材料和方法

30 例 32 个子宫肌瘤患者在 MRgHIFU 治疗前进行 MRI 研究，包括定量 T2 弛豫时间测量。T2 弛豫时间采用 16 个回波的多回波快速成像技术进行测量。采用非参数统计方法评估子宫肌瘤术前值与治疗结果（即无灌注体积比[NPVr]）之间的相关性。采用受试者工作特征（ROC）曲线分析和卡方检验比较基于 T2 弛豫时间的方法与现有的基于 T2 加权成像的方法。

结果

非参数关联度量显示 T2 弛豫时间值与 NPVr 之间存在统计学上显著的负相关。T2 弛豫时间分类（T2 I、T2 II 和 T2 III）导致整个模型的-值为 0.0019，而 Funaki 分类的-值为 0.56。T2 弛豫时间分类（T2 I 和 T2 II）导致整个模型的-值为 0.0024，而 SSI 分类的-值为 0.0749。