Ophthalmology Department (B.B.C., S.O.), Okan University, Faculty of Medicine, İstanbul, Turkey; Ophthalmology Department (H.B.A.), Okan University, Faculty of Medicine, İstanbul, Turkey; and Ophthalmology Department (E.T.), Okan University, Faculty of Medicine, İstanbul, Turkey.
Eye Contact Lens. 2021 Oct 1;47(10):552-554. doi: 10.1097/ICL.0000000000000819.
To evaluate the perilimbal vasculature of patients who wear contact lenses (CLs) overnight with optical coherence tomography angiography (OCTA) and compare the results with healthy population.
Forty-two patients were included in this observational study. The OCTA imaging was performed in the temporal quadrant of the perilimbal region using a swept-source optical coherence tomography system (Triton DRI-OCT; Topcon Corporation, Tokyo, Japan). The assessments were made in two depths: starting from the conjunctival epithelium to 200 μm scleral depth and the scleral depth between 200 and 1,000 μm. The vessel density, vessel length density, vessel diameter index, and fractal dimension were the main outcomes and compared between overnight CL users and healthy population.
Twenty-two patients who have been using CLs overnight for at least 3 months and 20 healthy individuals were included in the study. The vessel density at the superficial layer was significantly higher in the CL group compared with the control group (P<0.001). Vessel diameter index, vessel length density, and fractal dimension at the superficial layer did not differ between the groups (P>0.05 for all). There was no difference in the vessel density, vessel diameter index, vessel length density, and fractal dimension in the deep layer between the groups (P>0.05 for all).
Patients who use CL overnight exhibit increased vessel density in the superficial layers of the perilimbal region, which may suggest new vessel formation in the conjunctiva. Anterior segment OCTA may be useful to evaluate the initial changes in limbal vasculature in CL users.
利用光相干断层扫描血管造影术（OCTA）评估夜间佩戴隐形眼镜（CL）患者的周边角膜血管，并将结果与健康人群进行比较。
本观察性研究纳入 42 名患者。使用扫频源光学相干断层扫描系统（Triton DRI-OCT；Topcon 公司，东京，日本）在周边角膜的颞象限进行 OCTA 成像。评估在两个深度进行：从结膜上皮开始到 200μm 巩膜深度和 200μm 至 1000μm 的巩膜深度。血管密度、血管长度密度、血管直径指数和分形维数是主要观察指标，并在夜间 CL 使用者和健康人群之间进行比较。
本研究纳入了 22 名至少连续 3 个月夜间佩戴 CL 的患者和 20 名健康个体。与对照组相比，CL 组浅层的血管密度明显更高（P<0.001）。浅层的血管直径指数、血管长度密度和分形维数在两组之间无差异（P>0.05）。两组深层的血管密度、血管直径指数、血管长度密度和分形维数均无差异（P>0.05）。
夜间佩戴 CL 的患者周边角膜浅层的血管密度增加，这可能提示结膜新生血管形成。眼前节 OCTA 可能有助于评估 CL 使用者角膜缘血管的初始变化。
