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非阿片类镇痛药和新兴疗法。

Non-opioid Analgesics and Emerging Therapies.

机构信息

Department of Anesthesiology, Center for Pain Medicine, UC San Diego Health System, 9300 Campus Point Dr, MC 7651, San Diego, USA.

出版信息

Cancer Treat Res. 2021;182:125-142. doi: 10.1007/978-3-030-81526-4_9.

DOI:10.1007/978-3-030-81526-4_9
PMID:34542880
Abstract

Pain is a common and debilitating symptom of cancer. Cancer-related pain can occur at any point along the continuum from diagnosis to treatment to survivorship. A systematic review published in 2016 estimated the prevalence of cancer pain to be 55% in those undergoing antineoplastic treatment, 66.4% in advanced cancer, and 39.3% in the post-treatment population. Thirty-eight percent of cancer patients in this pooled analysis experienced moderate to severe pain.

摘要

疼痛是癌症常见且使人虚弱的症状。癌症相关的疼痛可能发生在从诊断到治疗到生存的整个过程中。2016 年发表的一项系统评价估计,接受抗肿瘤治疗的患者中癌症疼痛的患病率为 55%,晚期癌症为 66.4%,治疗后人群为 39.3%。在这项汇总分析中,38%的癌症患者经历了中重度疼痛。

相似文献

1
Non-opioid Analgesics and Emerging Therapies.非阿片类镇痛药和新兴疗法。
Cancer Treat Res. 2021;182:125-142. doi: 10.1007/978-3-030-81526-4_9.
2
The analgesic effect of rescue administration of intravenous acetaminophen in cancer patients may be associated with sex and opioid dose, and the effect would appear to patients administered under 45 mg/day opioid (oral morphine equivalents).癌症患者静脉注射对乙酰氨基酚进行解救给药的镇痛效果可能与性别和阿片类药物剂量有关,且该效果似乎在每日阿片类药物剂量低于45毫克(口服吗啡等效剂量)的患者中出现。
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First-line low-dose morphine is better for the control of moderate cancer pain than weaker opioids.对于中度癌痛的控制,一线低剂量吗啡比弱阿片类药物效果更好。
CA Cancer J Clin. 2016 May;66(3):177-8. doi: 10.3322/caac.21303. Epub 2016 Mar 21.
4
Tramadol with or without paracetamol (acetaminophen) for cancer pain.曲马多联合或不联合对乙酰氨基酚用于癌症疼痛治疗
Cochrane Database Syst Rev. 2017 May 16;5(5):CD012508. doi: 10.1002/14651858.CD012508.pub2.
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Managing childhood cancer pain into survivorship: recognition and emerging principles.管理儿童癌症生存者的疼痛:认识和新兴原则。
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Moderate to Severe Cancer Pain: Are We Taking Serious Action? The Opioid Prescribing Scenario in Portugal.中重度癌痛:我们是否在认真采取行动?葡萄牙的阿片类药物处方情况。
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CA Cancer J Clin. 2018 May;68(3):182-196. doi: 10.3322/caac.21453. Epub 2018 Mar 30.
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The relationship between pain, analgesics and survival in patients with advanced cancer; a secondary data analysis of the international European palliative care Cancer symptom study.晚期癌症患者疼痛、镇痛药与生存之间的关系;欧洲姑息治疗国际癌症症状研究的二次数据分析
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A concept analysis of analgesic nonadherence for cancer pain in a time of opioid crisis.阿片类药物危机时期癌症疼痛镇痛药物不依从的概念分析。
Nurs Outlook. 2020 Jan-Feb;68(1):83-93. doi: 10.1016/j.outlook.2019.06.017. Epub 2019 Jun 28.
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Pain management for patients with cancer.
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引用本文的文献

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Treatment of Neuropathic Pain Directly Due to Cancer: An Update.癌症直接导致的神经性疼痛的治疗:最新进展
Cancers (Basel). 2022 Apr 14;14(8):1992. doi: 10.3390/cancers14081992.

本文引用的文献

1
Cannabinoids and cancer pain: A new hope or a false dawn?大麻素与癌症疼痛:新的希望还是虚幻曙光?
Eur J Intern Med. 2018 Mar;49:30-36. doi: 10.1016/j.ejim.2018.01.020.
2
Leptomeningeal metastasis from systemic cancer: Review and update on management.系统性癌症的软脑膜转移:治疗综述与更新
Cancer. 2018 Jan 1;124(1):21-35. doi: 10.1002/cncr.30911. Epub 2017 Nov 22.
3
Opioids combined with antidepressants or antiepileptic drugs for cancer pain: Systematic review and meta-analysis.阿片类药物联合抗抑郁药或抗癫痫药治疗癌症疼痛:系统评价和荟萃分析。
Palliat Med. 2018 Jan;32(1):276-286. doi: 10.1177/0269216317711826. Epub 2017 Jun 12.
4
Breaking barriers to novel analgesic drug development.突破新型镇痛药研发的障碍。
Nat Rev Drug Discov. 2017 Aug;16(8):545-564. doi: 10.1038/nrd.2017.87. Epub 2017 Jun 9.
5
Continuous Intravenous Lidocaine Infusion for the Management of Pain Uncontrolled by Opioid Medications.持续静脉输注利多卡因用于治疗阿片类药物无法控制的疼痛。
J Pain Palliat Care Pharmacother. 2017 Sep-Dec;31(3-4):198-203. doi: 10.1080/15360288.2017.1313356. Epub 2017 May 10.
6
The efficacy and safety of intravenous lidocaine for analgesia in the older adult: a literature review.静脉注射利多卡因用于老年人镇痛的有效性和安全性:一项文献综述。
Br J Pain. 2017 Feb;11(1):23-31. doi: 10.1177/2049463716676205. Epub 2016 Oct 24.
7
Efficacy of Mirogabalin (DS-5565) on Patient-Reported Pain and Sleep Interference in Patients with Diabetic Neuropathic Pain: Secondary Outcomes of a Phase II Proof-of-Concept Study.米拉巴仑(DS-5565)治疗糖尿病周围神经病理性疼痛患者报告的疼痛和睡眠干扰的疗效:一项概念验证性 II 期研究的次要结局。
Pain Med. 2017 Nov 1;18(11):2198-2207. doi: 10.1093/pm/pnw342.
8
The role of drugs in bone pain.药物在骨痛中的作用。
Clin Cases Miner Bone Metab. 2016 May-Aug;13(2):93-96. doi: 10.11138/ccmbm/2016.13.2.093. Epub 2016 Oct 5.
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AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions.美国物理医学与康复学会慢性癌症疼痛病症诊断标准。
J Pain. 2017 Mar;18(3):233-246. doi: 10.1016/j.jpain.2016.10.020. Epub 2016 Nov 21.
10
Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline.成人癌症幸存者慢性疼痛管理:美国临床肿瘤学会临床实践指南。
J Clin Oncol. 2016 Sep 20;34(27):3325-45. doi: 10.1200/JCO.2016.68.5206. Epub 2016 Jul 25.