College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Pharmaceutical Care Department, King Abdullah Bin AbdulAziz University Hospital, Riyadh, Saudi Arabia.
Intervirology. 2022;65(2):104-109. doi: 10.1159/000519456. Epub 2021 Sep 20.
Many COVID-19 vaccines have been emerging with different efficacy and safety profiles. So far, very little attention has been paid to severity and reactogenicity of COVID-19 vaccine among healthcare workers. Thus, the aim of this study is to investigate the side effects associated with the first dose of AstraZeneca COVID-19 vaccine among healthcare workers (HCWs) and nonhealthcare workers (non-HCWs).
This is an observational cross-sectional study conducted at King Abdullah bin AbdulAziz University Hospital, Saudi Arabia, between February 28 and March 12, 2021. The major outcomes were the reported side effects of day 1, day 2, and day 3 after vaccination among HCWs and non-HCWs. Other outcomes included the onset and the duration of the reactions or the side effects that were reported.
A total of 526 participants completed the survey with 173 (32.8%) HCWs and the remaining majority were non-HCWs. Some of the most frequently reported side effects among the participants on the first day were muscle aches (49%), followed by fever (42%) and headache (40%). HCWs experienced more muscle aches, headache, sore throat, and abdominal pain, which were statically significant, compared to non-HCWs. The mean onset of symptoms was 16 (±15.3) h in the HCW arm compared with 12.2 (±10.2) h in non-HCWs (p = 0.0024). Furthermore, the mean duration of symptoms in the HCW group was 37 (±19) h compared with 32.3 (±13) h in the non-HCW group (p = 0.067).
The reported side effects were common but not pressing in both groups. HCW respondents appeared to have more COVID-19 vaccine-associated symptoms.
许多 COVID-19 疫苗具有不同的疗效和安全性特征。到目前为止，很少有人关注医护人员接种 COVID-19 疫苗的严重程度和不良反应。因此，本研究旨在调查医护人员（HCWs）和非医护人员（non-HCWs）接种阿斯利康 COVID-19 疫苗第一针后的副作用。
这是一项在沙特阿拉伯阿卜杜拉国王本阿卜杜勒-阿齐兹大学医院进行的观察性横断面研究，时间为 2021 年 2 月 28 日至 3 月 12 日。主要结局是 HCWs 和 non-HCWs 接种疫苗后第 1、2 和 3 天报告的副作用。其他结局包括报告的反应或副作用的发生和持续时间。
共有 526 名参与者完成了调查，其中 173 名（32.8%）为 HCWs，其余大多数为 non-HCWs。在第一天报告的副作用中，肌肉疼痛（49%）最常见，其次是发热（42%）和头痛（40%）。与 non-HCWs 相比，HCWs 经历了更多的肌肉疼痛、头痛、喉咙痛和腹痛，这具有统计学意义。HCW 组症状的平均发病时间为 16（±15.3）小时，non-HCWs 组为 12.2（±10.2）小时（p = 0.0024）。此外，HCW 组症状的平均持续时间为 37（±19）小时，non-HCWs 组为 32.3（±13）小时（p = 0.067）。
两组报告的副作用均常见，但不严重。HCW 受访者似乎有更多与 COVID-19 疫苗相关的症状。
