糖尿病相关外周动脉疾病治疗的不良预后：一项综合荟萃分析。
Adverse Prognosis of Peripheral Artery Disease Treatments Associated With Diabetes: A Comprehensive Meta-Analysis.
机构信息
Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, 198153Southern Medical University, Guangzhou, China.
Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
出版信息
Angiology. 2022 Apr;73(4):318-330. doi: 10.1177/00033197211042494. Epub 2021 Sep 21.
Many studies have investigated the influence of diabetes mellitus (DM) on outcomes in patients with peripheral artery disease (PAD). We performed a meta-analysis of the outcomes of PAD treatments in DM patients compared with those without DM. Long-term mortality was the primary endpoint. Secondary endpoints were in-hospital/30-day mortality, primary/secondary patency, amputation, and limb salvage. Thirty-one studies reporting 58113 patients were eligible for enrollment. The mean follow-up duration ranged from 1 to 89 months. DM was significantly associated with long-term mortality (relative risk (RR) = 1.67; 95% confidence intervals (CI), 1.43-1.94; < .001). DM was also associated with significantly lower primary patency (RR = 0.74; 95% CI, 0.58-0.95; = .001) and secondary patency (RR = 0.80; 95% CI, 0.67-0.96; = .009). DM is associated with worse outcomes and adverse prognosis of treatment in patients with PAD, and may therefore be a modifiable risk factor for poor prognosis in PAD patients.
许多研究调查了糖尿病（DM）对外周动脉疾病（PAD）患者结局的影响。我们对 DM 患者与非 DM 患者的 PAD 治疗结局进行了荟萃分析。主要终点为长期死亡率。次要终点为住院/30 天死亡率、一期/二期通畅率、截肢和肢体挽救。有 31 项研究报告了 58113 名符合条件的患者。平均随访时间从 1 至 89 个月不等。DM 与长期死亡率显著相关（相对风险（RR）=1.67；95%置信区间（CI），1.43-1.94；<0.001）。DM 还与一期通畅率（RR=0.74；95%CI，0.58-0.95；=0.001）和二期通畅率（RR=0.80；95%CI，0.67-0.96；=0.009）显著降低相关。DM 与 PAD 患者治疗结局较差和预后不良相关，因此可能是 PAD 患者预后不良的可改变风险因素。
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