Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, 198153Southern Medical University, Guangzhou, China.
Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Angiology. 2022 Apr;73(4):318-330. doi: 10.1177/00033197211042494. Epub 2021 Sep 21.
Many studies have investigated the influence of diabetes mellitus (DM) on outcomes in patients with peripheral artery disease (PAD). We performed a meta-analysis of the outcomes of PAD treatments in DM patients compared with those without DM. Long-term mortality was the primary endpoint. Secondary endpoints were in-hospital/30-day mortality, primary/secondary patency, amputation, and limb salvage. Thirty-one studies reporting 58113 patients were eligible for enrollment. The mean follow-up duration ranged from 1 to 89 months. DM was significantly associated with long-term mortality (relative risk (RR) = 1.67; 95% confidence intervals (CI), 1.43-1.94; < .001). DM was also associated with significantly lower primary patency (RR = 0.74; 95% CI, 0.58-0.95; = .001) and secondary patency (RR = 0.80; 95% CI, 0.67-0.96; = .009). DM is associated with worse outcomes and adverse prognosis of treatment in patients with PAD, and may therefore be a modifiable risk factor for poor prognosis in PAD patients.
许多研究调查了糖尿病（DM）对外周动脉疾病（PAD）患者结局的影响。我们对 DM 患者与非 DM 患者的 PAD 治疗结局进行了荟萃分析。主要终点为长期死亡率。次要终点为住院/30 天死亡率、一期/二期通畅率、截肢和肢体挽救。有 31 项研究报告了 58113 名符合条件的患者。平均随访时间从 1 至 89 个月不等。DM 与长期死亡率显著相关（相对风险（RR）=1.67；95%置信区间（CI），1.43-1.94；<0.001）。DM 还与一期通畅率（RR=0.74；95%CI，0.58-0.95；=0.001）和二期通畅率（RR=0.80；95%CI，0.67-0.96；=0.009）显著降低相关。DM 与 PAD 患者治疗结局较差和预后不良相关，因此可能是 PAD 患者预后不良的可改变风险因素。
