Yoshimatsu Kumiko
Institute for Genetic Medicine, Hokkaido University.
Uirusu. 2020;70(2):175-184. doi: 10.2222/jsv.70.175.
Chronic kidney disease of unknown etiology (CKDu) has emerged in endemic areas of Sri Lanka since the 1990s. The disease is a chronic but fatal disease. Until now, heavy metals and agrochemicals have been suspected as the cause of CKDu, but it has been still unknown. Recently, we have found a high seroprevalence to hantavirus in CKDu patients and reported that hantavirus infection is a risk of CKDu. Hantaviruses are rodent-borne zoonotic viruses. Here, I would like to introduce a story of the research from sero-epidemiology to the search for host animals.
自20世纪90年代以来，病因不明的慢性肾脏病（CKDu）在斯里兰卡的流行地区出现。这种疾病是一种慢性但致命的疾病。到目前为止，重金属和农用化学品一直被怀疑是CKDu的病因，但仍不清楚。最近，我们发现CKDu患者中汉坦病毒的血清阳性率很高，并报告说汉坦病毒感染是CKDu的一个风险因素。汉坦病毒是由啮齿动物传播的人畜共患病毒。在此，我想介绍一个从血清流行病学研究到寻找宿主动物的研究故事。
