Hassan Muhammad, Khan Naveed Ullah, Iqbal Mansoor, Jan Zakir, Rajput Haris Majid, Dewey Rebecca Susan, Badshah Mazhar
Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, Pakistan.
Department of Neurology, SZABMU, Pakistan.
Brain Hemorrhages. 2021 Dec;2(4):161-164. doi: 10.1016/j.hest.2021.09.004. Epub 2021 Sep 16.
The neurological manifestations of SARS-CoV-2 are wide-ranging from simple headache to severe demyelinating brain disease. This is a review of collected case reports of patients with SARS-CoV-2 with neurological manifestations presenting to the Pakistan Institute of Medical Sciences (PIMS). Neurological manifestations associated with SARS-CoV-2 such as encephalitis, acute cerebrovascular disease, encephalitis with chorea, post-COVID myositis and Guillain-Barré Syndrome (GBS) are of great concern but are often overlooked in the presence of life-threatening abnormal vital signs in severely ill SARS-CoV-2 patients. There is a need to diagnose these manifestations at the earliest opportunity to limit long-term consequences and complications. Much research is needed to explore the role of SARS-CoV-2 in causing these neurological manifestations by isolating it either from the cerebrospinal fluid (CSF) or the brain tissue of the deceased on autopsy. We also recommend exploring the risk factors that lead to the development of these neurological manifestations.
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的神经学表现范围广泛,从简单的头痛到严重的脱髓鞘性脑病。本文综述了向巴基斯坦医学科学研究所(PIMS)就诊的有神经学表现的SARS-CoV-2患者的病例报告。与SARS-CoV-2相关的神经学表现,如脑炎、急性脑血管疾病、伴有舞蹈症的脑炎、新冠后肌炎和吉兰-巴雷综合征(GBS),令人高度关注,但在重症SARS-CoV-2患者出现危及生命的异常生命体征时,这些表现往往被忽视。需要尽早诊断这些表现,以限制长期后果和并发症。需要进行大量研究,通过从尸检时死者的脑脊液(CSF)或脑组织中分离出SARS-CoV-2,来探索其在引起这些神经学表现中的作用。我们还建议探索导致这些神经学表现发生的危险因素。