饲养与口服补液对犊牛土霉素生物利用度的影响。
The influence of feeding and oral rehydration on the bioavailability of oxytetracycline in calves.
作者信息
Luthman J, Jacobsson S O
出版信息
Acta Vet Scand. 1987;28(3-4):343-8. doi: 10.1186/BF03548602.
The influence of feeding on the bioavailability of oxytetracycline was studied in preruminant calves. Oxytetracycline was given in water as a drench to fasting calves or was mixed in the milk replacer. Compared to water the bioavailability was significantly reduced (53.5%) when oxytetracycline was mixed in the milk re-placer. A further reduction, 83.3 %, occurred when the calves were treated one hour post milk feeding. Also concentrate was found to reduce the bioavailability. Very high serum levels were recorded when the drug was given in an oral rehydration solution, pH 4.9, containing glycine. The values obtained when an alkaline (pH 8.3) solution without glycine was used did not differ from the levels recorded when oxytetracycline was given in water. It was suggested that the use of oxytetra-cyclines in feeds may be questioned because of their well-known complex forming ability.
在反刍前犊牛中研究了喂食对土霉素生物利用度的影响。将土霉素以灌服的方式溶于水中给予禁食的犊牛，或将其混入代乳品中。与溶于水相比，当土霉素混入代乳品中时，其生物利用度显著降低（53.5%）。当犊牛在喂奶后1小时接受治疗时，生物利用度进一步降低，降至83.3%。还发现精饲料会降低生物利用度。当药物溶于pH值为4.9、含有甘氨酸的口服补液溶液中时，会记录到非常高的血清水平。当使用不含甘氨酸的碱性（pH 8.3）溶液时，所获得的值与土霉素溶于水时记录的水平没有差异。有人认为，由于土霉素众所周知的形成复合物的能力，其在饲料中的使用可能存在问题。
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