Division of Rheumatology, Department of Medicine.
Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, USA.
Curr Opin Ophthalmol. 2021 Nov 1;32(6):583-589. doi: 10.1097/ICU.0000000000000810.
Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations in multiple organs including the eyes. Several ocular manifestations like dry eye, retinopathy, and choroidopathy have been linked with specific systemic manifestations like lupus nephritis or CNS disease. Furthermore, the presence of ocular manifesattions can correlated with the severity of SLE. Finally, some medications used in the treatment of uveitis can present with lupus-like disease. Therefore, communication between the ophthalmologist and rheumatologist is vital.
Ocular and systemic manifestations of SLE can be linked by common pathological processes including immune complex deposition, complement fixation, and vascular injury. Recent research correlating ophthalmic imaging with SLE disease has yielded heterogeneous results likely due to the clinical heterogeneity of SLE, but molecular technologies have and will continue to yield contributions to the emergence of new therapeutics for the treatment of SLE.
Ocular manifestations are prevalent in patients with SLE. The association with certain manifestations and other disease manifestations highlights the importance of collaboration between the ophthalmologist and rheumatologist. Additional research utilizing clinico-molecular techniques will likely continue to improve our knowledge in the treatment of SLE in the future.
红斑狼疮（SLE）是一种自身免疫性疾病，可影响包括眼睛在内的多个器官。一些眼部表现，如干眼症、视网膜病变和脉络膜病变，与特定的全身表现如狼疮肾炎或中枢神经系统疾病有关。此外，眼部表现的存在与 SLE 的严重程度相关。最后，一些用于治疗葡萄膜炎的药物可能会出现狼疮样疾病。因此，眼科医生和风湿病学家之间的沟通至关重要。
SLE 的眼部和全身表现可通过共同的病理过程联系起来，包括免疫复合物沉积、补体固定和血管损伤。最近将眼科成像与 SLE 疾病相关联的研究得出了不一致的结果，这可能是由于 SLE 的临床异质性，但分子技术已经并将继续为治疗 SLE 的新疗法的出现做出贡献。
SLE 患者中常见眼部表现。与某些表现以及其他疾病表现的关联突出了眼科医生和风湿病学家之间合作的重要性。未来，利用临床-分子技术的进一步研究可能会继续提高我们对 SLE 治疗的认识。
