Kaur G, Baquer N Z, Singh R
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Biochem Int. 1987 May;14(5):939-47.
In this work, activities of hexokinase isoenzymes Type I and Type II were measured in the soluble and particulate fractions from the brain regions (cerebral hemispheres (cerebrum), cerebellum and brain stem) of the thyroidectomized adult rats as well as of the thyroidectomized rats administered with triiodothyronine. Thyroidectomy generally decreased the hexokinase activity associated with particulate and soluble fractions. Hexokinase Type II isoenzyme was more affected than the Type I isoenzyme. Administration of triiodothyronine to the hypothyroid rats abolished the effect of thyroidectomy. Adult brain enzymes have been generally considered not be affected by thyroid hormones. The data obtained in this work are suggestive of an effect of thyroid hormones on hexokinase in the adult brain. Since the effects of thyroidectomy on the energy metabolism of the heart tissue are well known, the heart tissue was also studied for comparison.
在这项研究中，我们测定了成年去甲状腺大鼠以及给予三碘甲状腺原氨酸的去甲状腺大鼠脑区（大脑半球（大脑）、小脑和脑干）可溶性和颗粒性组分中I型和II型己糖激酶的活性。甲状腺切除术通常会降低与颗粒性和可溶性组分相关的己糖激酶活性。II型己糖激酶同工酶比I型同工酶受影响更大。给甲状腺功能减退的大鼠施用三碘甲状腺原氨酸消除了甲状腺切除术的影响。一般认为成年脑酶不受甲状腺激素影响。这项研究中获得的数据表明甲状腺激素对成年大脑中的己糖激酶有影响。由于甲状腺切除术对心脏组织能量代谢的影响是众所周知的，因此也对心脏组织进行了研究以作比较。
