Department of Healthcare-Associated Infections and Antimicrobial Resistance, National Infection Service, Public Health England, Colindale, London, UK.
Department of Healthcare-Associated Infections and Antimicrobial Resistance, National Infection Service, Public Health England, Colindale, London, UK.
J Hosp Infect. 2022 Jan;119:175-181. doi: 10.1016/j.jhin.2021.08.027. Epub 2021 Sep 20.
Increases in hospital-onset Klebsiella spp. and Pseudomonas aeruginosa bacteraemia rates in England were observed between August 2020 and February 2021 to the highest levels recorded since the start of mandatory surveillance in April 2017. Cases were extracted from England's mandatory surveillance database for key Gram-negative bloodstream infections. Incidence rates for hospital-onset bacteraemia cases increased from 8.9 (N=255) to 14.9 (N=394) per 100,000 bed-days for Klebsiella spp. [incidence rate ratio (IRR) 1.7, P<0.001], and from 4.9 (N=139) to 6.2 (N=164) per 100,000 bed-days for P. aeruginosa (IRR 1.3, P<0.001) (August 2020-February 2021). These incidence rates were higher than the average rates observed during the same period in the previous 3 years. These trends coincided with an increase in the percentage of hospital-onset bacteraemia cases that were also positive for severe acute respiratory syndrome coronavirus-2.
2020 年 8 月至 2021 年 2 月期间，英国的医院获得性肺炎克雷伯菌和铜绿假单胞菌菌血症发病率上升，达到自 2017 年 4 月开始强制性监测以来的最高水平。这些病例是从英国强制性监测数据库中提取的，用于关键革兰氏阴性菌血流感染。医院获得性菌血症病例的发病率从每 10 万住院日 8.9 例（N=255）上升到 14.9 例（N=394），肺炎克雷伯菌的发病率上升（发病率比 [IRR] 1.7，P<0.001），铜绿假单胞菌的发病率从每 10 万住院日 4.9 例（N=139）上升到 6.2 例（N=164）（IRR 1.3，P<0.001）（2020 年 8 月至 2021 年 2 月）。这些发病率高于过去 3 年同期的平均发病率。这些趋势与医院获得性菌血症病例中同时对严重急性呼吸综合征冠状病毒-2 呈阳性的百分比增加相吻合。
