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CBFB-MYH11 融合转录本可区分具有不同分子特征和预后的急性髓系白血病。

CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes.

机构信息

Department of Pediatrics, University of California San Francisco, San Francisco, CA.

Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.

出版信息

Blood Adv. 2021 Dec 14;5(23):4963-4968. doi: 10.1182/bloodadvances.2021004965.

DOI:10.1182/bloodadvances.2021004965
PMID:34547772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9153007/
Abstract

transcripts and mutations predict relapse in AML. High-risk transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes.

摘要

转录本和突变可预测 AML 的复发。高危转录本与独特的转录景观相关，并上调早期造血基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/717a/9153007/81d0783cddab/advancesADV2021004965f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/717a/9153007/e10ab881b639/advancesADV2021004965f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/717a/9153007/81d0783cddab/advancesADV2021004965f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/717a/9153007/e10ab881b639/advancesADV2021004965f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/717a/9153007/81d0783cddab/advancesADV2021004965f2.jpg

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Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.
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