Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355, Poznan, Poland.
Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland.
Sci Rep. 2021 Sep 21;11(1):18706. doi: 10.1038/s41598-021-98232-0.
Thyroid diseases may cause a variety of functional and structural body changes, including eye and vision abnormalities, which can have a negative impact on a patient's well-being. However, only a few studies on the impact of other benign thyroid diseases on the visual process are available in the literature. In this study, using the Polish version of the thyroid-specific quality of life (ThyPROpl) questionnaire, we aimed to determine the self-reported influence of benign thyroid diseases (e.g., nodular goiter, toxic nodular goiter, Graves' disease, thyroid orbitopathy, Hashimoto's thyroiditis, and surgical hypothyroidism) on patients' eyes and vision. This was a prospective study. In total, 374 randomly selected euthyroid patients and 255 control subjects responded to the ThyPROpl questionnaire and the results were evaluated. Nearly 69% of the respondents reported that the most frequent condition was "reduced sight." Men most often reported wet/tearing eyes (66%). The occurrence of eyelid sacks or swollen eyelids (64%), ophthalmalgia (62%), and eye dryness (61%) was marked almost as often. In total, 29% of the patients reported diplopia, and it was found to be most prevalent among those with thyroid orbitopathy. Other complaints were similarly prevalent among all the subgroups. A positive correlation was also observed between the scores of the "eye symptoms" and other ailments. Except for swelling around the lower eyelids, patients with thyroid diseases more frequently experienced all of the ocular complaints analyzed in this study compared with controls. This study showed that eye complaints are common in patients with benign thyroid diseases and ocular disturbances have a negative impact on the overall quality of life of patients.
甲状腺疾病可引起多种功能和结构的身体变化，包括眼睛和视力异常，这会对患者的健康产生负面影响。然而，文献中仅有少数研究关注其他良性甲状腺疾病对视觉过程的影响。在这项研究中，我们使用波兰版甲状腺特异性生活质量（ThyPROpl）问卷，旨在确定良性甲状腺疾病（如结节性甲状腺肿、毒性结节性甲状腺肿、格雷夫斯病、甲状腺眼病、桥本甲状腺炎和甲状腺功能减退症）对患者眼睛和视力的自我报告影响。这是一项前瞻性研究。共有 374 名随机选择的甲状腺功能正常患者和 255 名对照者回答了 ThyPROpl 问卷，并对结果进行了评估。近 69%的受访者报告说，最常见的情况是“视力下降”。男性最常报告“流泪/溢泪”（66%）。睑袋或肿胀的眼睑（64%）、眼痛（62%）和眼睛干燥（61%）的发生率几乎一样高。共有 29%的患者报告有复视，且在甲状腺眼病患者中最为常见。其他的抱怨在所有亚组中也同样常见。“眼部症状”评分与其他疾病之间也存在正相关。除了下眼睑周围肿胀外，与对照组相比，患有甲状腺疾病的患者更频繁地经历本研究分析的所有眼部不适。这项研究表明，眼部不适在患有良性甲状腺疾病的患者中很常见，眼部障碍会对患者的整体生活质量产生负面影响。
