Melcangi R C, Celotti F, Poletti A, Negri-Cesi P, Martini L
Institute of Endocrinology, University of Milan, Italy.
Steroids. 1987 Apr-May;49(4-5):259-70. doi: 10.1016/0039-128x(87)90003-1.
Previous studies have shown that the central nervous system is able to convert testosterone into 17-beta-hydroxy-5-alpha-androstan-3-one (DHT), by the action of the enzyme 5-alpha-reductase. The data here presented show that, in the brain of the rat and the mouse of both sexes, the 5-alpha-reductase activity is more concentrated in the subcortical white matter than in the hypothalamus and in the cerebral cortex. The enzymatic activity is apparently higher in the rat than in the mouse brain. The formation of DHT in the subcortical white matter, in the hypothalamus and in the cerebral cortex of both rats and mice does not show any sexual difference. Moreover, in the rat no effect of short- or long-term castration or neonatal castration or testosterone replacement could be observed on the formation of DHT in the three brain structures considered (even in the subcortical white matter, the cerebral tissue more active in converting testosterone into DHT). The present data support the view that the 5-alpha-reductase present in the brain is not under androgenic control.
先前的研究表明，中枢神经系统能够通过5-α还原酶的作用将睾酮转化为17-β-羟基-5-α-雄甾烷-3-酮（双氢睾酮，DHT）。此处呈现的数据表明，在雄性和雌性大鼠及小鼠的大脑中，5-α还原酶活性在下皮质白质中比在下丘脑和大脑皮层中更集中。该酶活性在大鼠大脑中显然比在小鼠大脑中更高。大鼠和小鼠的下皮质白质、下丘脑及大脑皮层中双氢睾酮的形成均未表现出任何性别差异。此外，在大鼠中，未观察到短期或长期去势、新生期去势或睾酮替代对所研究的三个脑结构中双氢睾酮形成的影响（即使在下皮质白质中，该脑组织在将睾酮转化为双氢睾酮方面更活跃）。目前的数据支持这样一种观点，即大脑中存在的5-α还原酶不受雄激素控制。
