高分子量激肽原对凝血酶诱导的血小板聚集的抑制作用。
Inhibition of thrombin-induced platelet aggregation by high molecular weight kininogen.
作者信息
Puri R N, Gustafson E J, Zhou F X, Bradford H, Colman R F, Colman R W
机构信息
Thrombosis Research Center, Temple University, Philadelphia, PA 19140.
出版信息
Trans Assoc Am Physicians. 1987;100:232-40.
PMID:3455067
Abstract
- Thrombin-induced platelet aggregation and cleavage of [3H]FSBA-labeled aggregin is mediated by platelet calpain. 2. Plasma HMWK inhibits platelet aggregation and cleavage of aggregin in intact platelets, indirectly by thrombin and directly by calpain. 3. Inhibition of thrombin-induced platelet aggregation by HMWK is specific for this proteolytic enzyme. 4. HMWK is the major inhibitor of thrombin-induced activation of platelets in plasma.
摘要
- 凝血酶诱导的血小板聚集以及[3H]FSBA标记的聚集蛋白的裂解是由血小板钙蛋白酶介导的。2. 血浆高分子量激肽原（HMWK）间接通过凝血酶、直接通过钙蛋白酶抑制完整血小板中聚集蛋白的聚集和裂解。3. HMWK对凝血酶诱导的血小板聚集的抑制作用对这种蛋白水解酶具有特异性。4. HMWK是血浆中凝血酶诱导的血小板激活的主要抑制剂。
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