脑脊液铁蛋白比值可作为帕金森病进展的潜在标志物。
Cerebrospinal Fluid Iron-Ferritin Ratio as a Potential Progression Marker for Parkinson's Disease.
机构信息
Department of Neurology, University Medical Center Göttingen, Goettingen, Germany.
Research Unit Analytical BioGeoChemistry, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.
出版信息
Mov Disord. 2021 Dec;36(12):2967-2969. doi: 10.1002/mds.28790. Epub 2021 Sep 23.
PMID:34553776
Abstract
Longitudinal PD CSF samples were subjected to ICP-MS and the total amount of iron and other bioelements was quantified. Additionally, ferritin and protein biomarkers of neurodegeneration were measured. Over time, mean iron levels significantly increased while levels of ferritin decreased.
摘要
对纵向 PD 脑脊液样本进行 ICP-MS 分析，定量测定铁和其他生物元素的总量。此外，还测量了铁蛋白和神经退行性变的蛋白质生物标志物。随着时间的推移，铁水平呈显著升高趋势，而铁蛋白水平下降。
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