Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
J Neurochem. 2021 Dec;159(5):804-825. doi: 10.1111/jnc.15519. Epub 2021 Oct 9.
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While β-amyloid plaque and neurofibrillary tangles define the pathology of the disease, the mechanism of neurodegeneration is uncertain. Ferroptosis is an iron-mediated programmed cell death mechanism characterised by phospholipid peroxidation that has been observed in clinical AD samples. This review will outline the growing molecular and clinical evidence implicating ferroptosis in the pathogenesis of AD, with implications for disease-modifying therapies.
阿尔茨海默病（AD）是最常见的痴呆症形式，其复杂的病理生理学尚未完全阐明。虽然β-淀粉样斑块和神经原纤维缠结定义了疾病的病理学，但神经退行性变的机制尚不确定。铁死亡是一种铁介导的程序性细胞死亡机制，其特征是脂质过氧化，在临床 AD 样本中观察到。这篇综述将概述越来越多的分子和临床证据表明铁死亡与 AD 的发病机制有关，并对疾病修饰治疗具有启示意义。
