Am J Vet Res. 2021 Oct;82(10):795-801. doi: 10.2460/ajvr.82.10.795.
To determine the effects of IV administration of pimobendan on hemodynamic indices and indices of left atrial (LA) longitudinal strain by speckle-tracking echocardiography in healthy dogs.
6 healthy Beagles.
After the dogs were anesthetized, the right heart was catheterized and 2-D conventional and speckle-tracking echocardiography were performed before and after IV administration of 0.15 mg of pimobendan/kg. Speckle-tracking echocardiography was performed to assess the 3 LA phasic functions through LA deformation (longitudinal strain and strain rate) and volumetric analyses.
Pimobendan significantly increased stroke volume and cardiac output and decreased systemic vascular resistance. Pimobendan significantly improved left ventricular function assessed by the Tei index and LA booster pump function assessed by LA longitudinal strain and change in fractional volume during atrial systole. Indices of LA reservoir and conduit function were unchanged.
In healthy dogs, IV administration of pimobendan improved the indices of LA booster pump function but had no effect on the indices of LA reservoir and conduit functions. Further studies are needed to validate whether these results can be extrapolated to dogs with myxomatous mitral valve disease.
通过斑点追踪超声心动图评估静脉注射匹莫苯丹对健康犬血流动力学指标和左心房（LA）纵向应变指标的影响。
6 只健康比格犬。
在犬麻醉后，经右心导管插入术，在静脉注射 0.15mg/kg 匹莫苯丹前后进行二维常规和斑点追踪超声心动图检查。通过 LA 变形（纵向应变和应变率）和容积分析对 LA 3 个时相功能进行斑点追踪超声心动图评估。
匹莫苯丹可显著增加每搏量和心输出量，降低体循环血管阻力。匹莫苯丹可显著改善 Tei 指数评估的左心室功能和 LA 纵向应变及心房收缩期左房容积变化评估的 LA 辅助泵功能。LA 储备和传导功能的指标无变化。
在健康犬中，静脉注射匹莫苯丹可改善 LA 辅助泵功能的指标，但对 LA 储备和传导功能的指标无影响。需要进一步的研究来验证这些结果是否可以推广到患有黏液样二尖瓣病变的犬。
