Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki city, Miyazaki, 889-1692, Japan.
Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki city, Miyazaki, 889-1692, Japan.
Eur J Pharmacol. 2021 Nov 15;911:174513. doi: 10.1016/j.ejphar.2021.174513. Epub 2021 Sep 20.
The roles of serotonin (5-HT) and/or noradrenaline in acute pruriceptive processing have been demonstrated using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant; however, the involvement of 5-HT in acute pruriceptive processing has not yet been elucidated in detail. Scratching events induced by chloroquine (CQ) were attenuated by the administration of milnacipran or mirtazapine, and these effects were reversed by a treatment with ondansetron, a 5-HT antagonist, or SB26970, a 5-HT antagonist. CQ-induced scratching events were also ameliorated by the intrathecal administration of 5-HT, SR572227A and RS56812 (5-HT agonists), and LP211 and LP44 (5-HT agonists), indicating the modulation of CQ-induced scratching events by 5-HT and noradrenaline. By contrast, histamine-induced scratching events were not markedly affected by the administration of 5-HT and 5-HT agonists, whereas 5-HT agonists exerted attenuating effects. Similarly, they were not clearly reversed by the administration of the 5-HT antagonist, unlike a 5-HT antagonist. Therefore, 5-HT is involved in the attenuating effects of milnacipran and mirtazapine on CQ- and histamine-induced scratching events, and 5-HT and 5-HT receptors play different roles in pruriceptive processing induced by histamine or CQ.
5-羟色胺（5-HT）和/或去甲肾上腺素在急性瘙痒性加工中的作用已被抗抑郁药所证明，如米那普仑，一种 5-HT 和去甲肾上腺素再摄取抑制剂，和米氮平，一种去甲肾上腺素和特异性 5-HT 抗抑郁药；然而，5-HT 在急性瘙痒性加工中的参与尚未详细阐明。氯喹（CQ）诱导的搔抓事件被米那普仑或米氮平的给药所减弱，这些作用被 5-HT 拮抗剂昂丹司琼或 5-HT 拮抗剂 SB26970 逆转。5-HT、SR572227A 和 RS56812（5-HT 激动剂）和 LP211 和 LP44（5-HT 激动剂）的鞘内给药也改善了 CQ 诱导的搔抓事件，表明 5-HT 和去甲肾上腺素对 CQ 诱导的搔抓事件的调节。相比之下，5-HT 和 5-HT 激动剂的给药对组胺诱导的搔抓事件没有明显影响，而 5-HT 激动剂则产生减弱作用。同样，它们也没有被 5-HT 拮抗剂明显逆转，而不像 5-HT 拮抗剂那样。因此，5-HT 参与了米那普仑和米氮平对 CQ 和组胺诱导的搔抓事件的减弱作用，5-HT 和 5-HT 受体在组胺或 CQ 诱导的瘙痒性加工中发挥不同的作用。
