外源性多巴胺对新生大鼠脑内下丘脑多巴胺和去甲肾上腺素浓度的影响。

Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats.

作者信息

Ohkura T, Lee J W, Hagino N

机构信息

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.

出版信息

Int J Dev Neurosci. 1986;4(2):129-33. doi: 10.1016/0736-5748(86)90037-7.

DOI:10.1016/0736-5748(86)90037-7

PMID:3455577

Abstract

Hypothalamic dopamine (DA) and norepinephrine (NE) concentrations were studied in the neonatal rats after acute (postnatal day 4) or chronic (postnatal days 1-10) DA injections (0.5 mg in 5% dextrose in 0.45% saline). Acute injection of DA twice on postnatal day 4 resulted in an increase of hypothalamic DA and NE concentrations 16 hr later. Chronic treatment with the DA (twice in a day) for 10 days resulted in a reduction of NE concentration in the hypothalamus. The results of these studies suggest that the amount and duration of exposure to exogenous DA during postnatal development may result in divergent effects on hypothalamic catecholamine concentration.

摘要

研究了新生大鼠在急性（出生后第4天）或慢性（出生后第1 - 10天）注射多巴胺（DA）（0.5毫克溶于0.45%盐水中的5%葡萄糖溶液）后的下丘脑多巴胺（DA）和去甲肾上腺素（NE）浓度。出生后第4天急性注射两次DA导致16小时后下丘脑DA和NE浓度升高。用DA（每天两次）进行10天的慢性治疗导致下丘脑NE浓度降低。这些研究结果表明，出生后发育期间暴露于外源性DA的量和持续时间可能会对下丘脑儿茶酚胺浓度产生不同的影响。