位置很重要：在单细胞水平解析弥漫型胃癌。
Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level.
机构信息
Division of Surgical Oncology, Department of Surgery, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.
出版信息
Clin Cancer Res. 2021 Dec 1;27(23):6284-6286. doi: 10.1158/1078-0432.CCR-21-2935. Epub 2021 Sep 23.
Abstract
Spatial single-cell transcriptomics of primary patient diffuse type gastric cancer reveals distinct cancer and stromal cell differences based on location. Expression of CCL2 by stromal cells in deep tumor regions is highlighted as potentially driving the immunosuppressive microenvironment and enhancing (directly or indirectly) the invasive capacity of tumor cells..
摘要
原发性弥漫型胃癌的空间单细胞转录组学研究揭示了基于位置的肿瘤细胞和基质细胞的明显差异。深肿瘤区域基质细胞表达的 CCL2 被突出为潜在的驱动免疫抑制微环境，并增强（直接或间接）肿瘤细胞的侵袭能力。
相似文献
1
Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level.位置很重要：在单细胞水平解析弥漫型胃癌。
Clin Cancer Res. 2021 Dec 1;27(23):6284-6286. doi: 10.1158/1078-0432.CCR-21-2935. Epub 2021 Sep 23.
2
Spatially Distinct Reprogramming of the Tumor Microenvironment Based On Tumor Invasion in Diffuse-Type Gastric Cancers.基于弥漫型胃癌肿瘤侵袭的肿瘤微环境空间特异性重编程
Clin Cancer Res. 2021 Dec 1;27(23):6529-6542. doi: 10.1158/1078-0432.CCR-21-0792. Epub 2021 Aug 12.
3
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in gastric cancer. bulk 和单细胞转录组谱分析揭示了胃癌中的代谢异质性。
Sci Rep. 2023 May 31;13(1):8787. doi: 10.1038/s41598-023-35395-y.
4
Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer.胃癌中单细胞谱系状态、肿瘤微环境和亚型特异性表达程序图谱。
Cancer Discov. 2022 Mar 1;12(3):670-691. doi: 10.1158/2159-8290.CD-21-0683.
5
Stromal-Based Signatures for the Classification of Gastric Cancer.基于基质的胃癌分类标志物。
Cancer Res. 2016 May 1;76(9):2573-86. doi: 10.1158/0008-5472.CAN-16-0022.
6
THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling.通过转录组表达谱分析鉴定的弥漫型胃腺癌新型基质分子 THBS4。
Mod Pathol. 2011 Oct;24(10):1390-403. doi: 10.1038/modpathol.2011.99. Epub 2011 Jun 24.
7
Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment.胃癌微环境中新基因特征的预后意义。
Med Sci Monit. 2020 Aug 2;26:e924604. doi: 10.12659/MSM.924604.
8
Mining TCGA database for genes of prognostic value in gastric cancer microenvironment.从 TCGA 数据库中挖掘对胃癌微环境有预后价值的基因。
J Cell Mol Med. 2020 Oct;24(19):11120-11132. doi: 10.1111/jcmm.15595. Epub 2020 Aug 20.
9
New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression.深入了解富含淋巴细胞基质的胃癌炎症肿瘤免疫微环境：从形态学和数字分析到基因表达。
Gastric Cancer. 2019 Jan;22(1):77-90. doi: 10.1007/s10120-018-0836-8. Epub 2018 May 19.
10
Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions.胰腺导管腺癌原发肿瘤和转移病灶肿瘤和基质区室的单细胞转录组分析。
Genome Med. 2020 Sep 29;12(1):80. doi: 10.1186/s13073-020-00776-9.
引用本文的文献
1
Drug-induced senescence by aurora kinase inhibitors attenuates innate immune response of macrophages on gastric cancer organoids. Aurora 激酶抑制剂诱导的衰老可减弱胃癌类器官中巨噬细胞的固有免疫反应。
Cancer Lett. 2024 Aug 28;598:217106. doi: 10.1016/j.canlet.2024.217106. Epub 2024 Jul 9.
本文引用的文献
1
Spatially Distinct Reprogramming of the Tumor Microenvironment Based On Tumor Invasion in Diffuse-Type Gastric Cancers.基于弥漫型胃癌肿瘤侵袭的肿瘤微环境空间特异性重编程
Clin Cancer Res. 2021 Dec 1;27(23):6529-6542. doi: 10.1158/1078-0432.CCR-21-0792. Epub 2021 Aug 12.
2
More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis.不只是有吸引力：CCL2 如何影响髓系细胞行为超出趋化作用。
Front Immunol. 2019 Dec 13;10:2759. doi: 10.3389/fimmu.2019.02759. eCollection 2019.
3
Integrative single-cell analysis.整合单细胞分析。
Nat Rev Genet. 2019 May;20(5):257-272. doi: 10.1038/s41576-019-0093-7.
4
Gastric cancer.胃癌。
Lancet. 2016 Nov 26;388(10060):2654-2664. doi: 10.1016/S0140-6736(16)30354-3. Epub 2016 May 5.
5
Targeting the CCL2-CCR2 signaling axis in cancer metastasis.靶向CCL2-CCR2信号轴以治疗癌症转移。
Oncotarget. 2016 May 10;7(19):28697-710. doi: 10.18632/oncotarget.7376.
Zotero 插件