Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
Central Laboratory of Renmin Hospital, Wuhan, China.
J Cell Mol Med. 2020 Oct;24(19):11120-11132. doi: 10.1111/jcmm.15595. Epub 2020 Aug 20.
Gastric cancer (GC) is the sixth most common malignancy and the third leading cause of cancer-related death worldwide. Emerging evidence suggests that tumour microenvironment cells play a vital role in the development and prognosis of GC. To investigate the possible effect of stromal scores and immune scores on the overall survival (OS) on the GC patients, we divided GC patients into 'high' and 'low' groups based on their stromal and immune scores, and found differentially expressed genes related to prognosis of GC patients. Functional enrichment analysis and GSVA further revealed that focal adhesion and ECM-receptor interaction are associated with GC patients' survival. Finally, we analysed the effects of genes commonly involved in focal adhesion and ECM-receptor interaction on GC patients' survival and validated our results in another GC cohort from GEO data sets. In conclusion, we obtained a list of tumour microenvironment-related genes that predict poor prognosis in GC patients.
胃癌（GC）是全球第六大常见恶性肿瘤，也是癌症相关死亡的第三大主要原因。新出现的证据表明，肿瘤微环境细胞在 GC 的发生和预后中起着至关重要的作用。为了研究基质评分和免疫评分对 GC 患者总生存期（OS）的可能影响，我们根据基质和免疫评分将 GC 患者分为“高”和“低”两组，并发现了与 GC 患者预后相关的差异表达基因。功能富集分析和 GSVA 进一步表明，局灶黏附和 ECM 受体相互作用与 GC 患者的生存有关。最后，我们分析了共同涉及局灶黏附和 ECM 受体相互作用的基因对 GC 患者生存的影响，并在 GEO 数据集中的另一个 GC 队列中验证了我们的结果。总之，我们获得了一组与 GC 患者不良预后相关的肿瘤微环境相关基因。
