Vaughan J P, Menu J P, Kihama F, Brooke D, Kiwia A, Mohamed S A
Trop Geogr Med. 1977 Dec;29(4):369-73.
In a coastal population in whom anaemia was common, two randomised controlled trials were undertaken to investigate the effectiveness of treating iron deficiency anaemia at a dispensary and at primary schools. For anaemic adult villagers treated at a dispensary, one dose of tetrachlorethylene for hookworm infection and a once per week visit to collect medicines were found to be satisfactory. A small but significant increase in haemoglobin level was produced by four weeks oral iron therapy, but this was only maintained after seven months by the group that had initially also received tetrachlorethylene. In children (5-14 years) no significant rise in haemoglobin level was obtained by using oral iron and/or TCE, either at the dispensary or at the primary schools. This suggests that malaria was a more potent cause of anaemia in these children.
在一个贫血普遍的沿海人群中，进行了两项随机对照试验，以研究在诊疗所和小学治疗缺铁性贫血的效果。对于在诊疗所接受治疗的贫血成年村民，一剂用于治疗钩虫感染的四氯乙烯以及每周一次的取药就诊被认为是令人满意的。四周的口服铁剂治疗使血红蛋白水平有小幅但显著的升高，但只有最初也接受了四氯乙烯治疗的组在七个月后仍维持这一水平。在儿童（5至14岁）中，无论是在诊疗所还是在小学，使用口服铁剂和/或四氯乙烯均未使血红蛋白水平显著升高。这表明疟疾是这些儿童贫血的一个更主要原因。
