Naito M, Ito A, Watanabe H, Kawashima K, Aoyama H
J Natl Cancer Inst. 1986 Jan;76(1):115-8.
The carcinogenicity of o-ethoxybenzamide (CAS: 938-73-8), which is also called ethenzamide and which is widely used as an antipyretic anodyne in Japan, was examined in 298 (C57BL/6N X C3H/HeN)F1 mice. Groups of males and females were fed a diet containing 0 (control), 0.4, or 1.2% o-ethoxybenzamide for 96 weeks and sacrificed at the 100th week. Among the male mice fed the higher dose of the drug, the total incidence of liver cell tumors was 68%, with 18% of the mice developing hepatocellular carcinomas; both yields were significantly higher than those in the controls. In o-ethoxybenzamide-treated male mice the multiplicities of the hepatic cell tumors were also significantly higher than the multiplicity of the hepatic tumor in male control mice. A dose-response relationship with regard to both incidence and multiplicities of hepatic cell tumors in male mice was observed. In female mice fed o-ethoxybenzamide the incidence and multiplicities of the liver cell tumors were increased compared to those of the controls, but statistical significance was observed only in the multiplicity of tumors in mice given the lower dose. In both sexes hepatic cell tumors developed earlier than in the controls. These results show that o-ethoxybenzamide enhances the development of hepatic cell tumors in male (C57BL/6N X C3H/HeN)F1 mice.
邻乙氧基苯甲酰胺（CAS：938 - 73 - 8，也称为乙苯酰胺）在日本被广泛用作解热镇痛药，本研究在298只（C57BL/6N×C3H/HeN）F1小鼠中检测了其致癌性。将雄性和雌性小鼠分为几组，分别喂食含0（对照）、0.4%或1.2%邻乙氧基苯甲酰胺的饲料，持续96周，并在第100周处死。在喂食较高剂量药物的雄性小鼠中，肝细胞肿瘤的总发生率为68%，其中18%的小鼠发生肝细胞癌；这两个发生率均显著高于对照组。在接受邻乙氧基苯甲酰胺处理的雄性小鼠中，肝细胞肿瘤的多发性也显著高于雄性对照小鼠中的肝肿瘤多发性。观察到雄性小鼠肝细胞肿瘤的发生率和多发性均存在剂量 - 反应关系。在喂食邻乙氧基苯甲酰胺的雌性小鼠中，肝细胞肿瘤的发生率和多发性均高于对照组，但仅在给予较低剂量的小鼠中，肿瘤多发性具有统计学意义。在两性中，肝细胞肿瘤的发生均早于对照组。这些结果表明，邻乙氧基苯甲酰胺可促进雄性（C57BL/6N×C3H/HeN）F1小鼠肝细胞肿瘤的发生。
