Ershler W B, Berman E, Moore A L
J Natl Cancer Inst. 1986 Jan;76(1):81-5.
Recently, it has been demonstrated that the immune function is preserved longer and spontaneous tumors occur less frequently in calorie-restricted (but not malnourished) mice. In the present report the effect of similar dietary manipulation on tumor growth, metastases, and survival was studied. C57BL/6 mice were fed regular laboratory diets, either restricted in calories or not restricted, and later inoculated with B16 melanoma sc, iv, or ip. Local tumor growth was found to be slower; however, survival after ip injection was no different, and the number of pulmonary metastatic colonies after iv injection was greater for the underfed mice. In this weakly immunogenic tumor model, factors in addition to immunity influenced tumor growth and were altered by calorie restriction.
最近有研究表明，在热量受限（但非营养不良）的小鼠中，免疫功能维持时间更长，自发性肿瘤的发生频率更低。在本报告中，研究了类似饮食调控对肿瘤生长、转移和存活的影响。给C57BL/6小鼠喂食常规实验室饮食，分为热量受限组和非热量受限组，随后通过皮下、静脉或腹腔注射接种B16黑色素瘤。发现局部肿瘤生长较慢；然而，腹腔注射后的存活率并无差异，静脉注射后，进食不足的小鼠肺部转移瘤集落数量更多。在这个弱免疫原性肿瘤模型中，除免疫因素外，其他因素也影响肿瘤生长，并且会因热量限制而改变。
