人类急性单核细胞白血病中11号染色体q23区与9号染色体p22区易位相关的干扰素基因和c-ets-1基因

Interferon and c-ets-1 genes in the translocation (9;11)(p22;q23) in human acute monocytic leukemia.

作者信息

Diaz M O, Le Beau M M, Pitha P, Rowley J D

出版信息

Science. 1986 Jan 17;231(4735):265-7. doi: 10.1126/science.3455787.

Abstract

Gene probes for interferons alpha and beta 1 and v-ets were hybridized to metaphase chromosomes from three patients with acute monocytic leukemia who had a chromosomal translocation, t(9;11)(p22;q23). The break in the short arm of chromosome 9 split the interferon genes, and the interferon-beta 1 gene was translocated to chromosome 11. The c-ets-1 gene was translocated from chromosome 11 to the short arm of chromosome 9 adjacent to the interferon genes. No DNA rearrangement was observed when these probes were hybridized to genomic DNA from leukemic cells of two of the patients. The results suggest that the juxtaposition of the interferon and c-ets-1 genes may be involved in the pathogenesis of human monocytic leukemia.

摘要

针对α干扰素、β1干扰素和v-ets的基因探针与三名患有急性单核细胞白血病且存在染色体易位t(9;11)(p22;q23)的患者的中期染色体进行杂交。9号染色体短臂上的断裂点将干扰素基因分开，β1干扰素基因易位至11号染色体。c-ets-1基因从11号染色体易位至9号染色体短臂上靠近干扰素基因的位置。当这些探针与其中两名患者白血病细胞的基因组DNA杂交时，未观察到DNA重排。结果表明，干扰素基因与c-ets-1基因的并置可能参与了人类单核细胞白血病的发病机制。