Translocation (9;11;22)(p22;q23;q11). A new type of complex variant translocation of t(9;11)(p22;q23) with MLL rearrangement.

作者信息

Takahashi N, Miura I, Ohshima A, Nimura T, Hashimoto K, Hatano Y, Utsumi S, Kume M, Saito K, Kobayashi Y, Saito M, Seto M, Ueda R, Miura A B

机构信息

Third Department of Internal Medicine, Akita University School of Medicine, Japan.

出版信息

Cancer Genet Cytogenet. 1996 May;88(1):26-9. doi: 10.1016/0165-4608(95)00297-9.

We describe a patient with acute monocytic leukemia (M5a, FAB classification) associated with a new type of variant translocation (9;11). Southern blot analysis showed the rearrangement of the MLL (ALL-1/HRX) gene at 11q23. Fluorescence in situ hybridization (FISH) with painting probes of chromosomes 9, 11, and 22 revealed the translocation as t(9;11;22) (p22;q23;q11). This is more evidence that the production of chimeric mRNA following the translocation of the LTG9 (MLLT3/AF9) gene at 9p22 to 11q is a critical event in this leukemia subtype.