血清糖类抗原（CA）19-9检测在胃癌诊断中的应用
[Assay of serum carbohydrate antigen (CA) 19-9 in the diagnosis of gastric cancer].
作者信息
Nishida K, Yamamoto T, Yoshioka K, Iida M, Miyagawa H, Yoshikawa T, Sugino S, Kondo M
出版信息
Gan To Kagaku Ryoho. 1986 Jan;13(1):101-8.
The levels of the serum carbohydrate antigen (CA) 19-9 were assayed in 284 cases including 77 patients with gastric cancer. The CA 19-9 levels were positive in 38% of gastric cancer cases, and they were significantly higher than those of benign gastric diseases. Extremely increased levels were found in advanced gastric cancer, but not in early gastric cancer. There was no significant correlation between CA 19-9 and CEA, and CA 19-9 seemed to be superior to CEA in specificity for gastric cancer, but inferior in sensitivity. Thus, the assay of CA 19-9 in combination with CEA could be helpful in the differentiation between benign and malignant gastric diseases.
对包括77例胃癌患者在内的284例患者检测了血清糖类抗原（CA）19-9水平。38%的胃癌病例CA 19-9水平呈阳性，且显著高于良性胃部疾病患者。进展期胃癌中发现CA 19-9水平极度升高，而早期胃癌中未发现。CA 19-9与癌胚抗原（CEA）之间无显著相关性，CA 19-9在胃癌特异性方面似乎优于CEA，但敏感性较差。因此，联合检测CA 19-9和CEA有助于鉴别胃部良性和恶性疾病。
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