Department of Infectious Diseases, Tropical Diseases and Hepatology, Medical University, Warsaw, Poland.
Department of Paediatric Gastroenterology and Nutrition, Medical University, Warsaw, Poland.
Ann Agric Environ Med. 2021 Sep 16;28(3):404-408. doi: 10.26444/aaem/127180. Epub 2020 Sep 14.
Eosinophilic esophagitis (EoE) is an inflammatory immune-mediated oesophageal disease of growing prevalence. The aim of this study is to characterise the clinical symptoms, endoscopic features and histological findings, as well as their possible correlations, in newly-diagnosed EoE paediatric patients.
Between 2009-2018, the clinical records of patients diagnosed with EoE at the Paediatric Hospital in Warsaw, Poland, were retrospectively reviewed. Inclusion criteria were upper gastrointestinal tract symptoms in association with oesophageal mucosal biopsy specimens containing not less than 15 intraepithelial eosinophils per hpf. The prevalence and the possible correlations between symptoms, endoscopic features and the density of eosinophilic infiltration were analysed; the medical history of the comorbidities were also assessed.
The study included 47 children (median age 9.5 years). The most common clinical symptoms were abdominal pain (53%) and GERD-like symptoms (26%). The most common macroscopic changes were white plaques and exudates in 47% and furrows in 34%. A macroscopically normal oesophagus was observed in 28% of the children. The median number of eosinophils was estimated to be 45 eosinophils/hpf (IQR: 30-60), and no significant differences were found between the density of eosinophil infiltration and clinical symptoms or endoscopic features. Moreover, 70% of the children had a history of an allergy disease, older children (>3 years) tended to have pollen allergy more often than younger children (p<0.05).
The density of oesophageal eosinophilia does not correlate with symptoms or endoscopic findings in children with newl-diagnosed EoE.
嗜酸性食管炎（EoE）是一种日益普遍的炎症性免疫介导的食管疾病。本研究旨在描述新诊断的嗜酸细胞性食管炎儿科患者的临床症状、内镜特征和组织学发现及其可能的相关性。
2009 年至 2018 年间，回顾性分析了波兰华沙儿科医院诊断为嗜酸细胞性食管炎的患者的临床记录。纳入标准为上消化道症状伴食管黏膜活检标本中每高倍镜视野（hpf）至少有 15 个上皮内嗜酸性粒细胞。分析了症状、内镜特征和嗜酸性粒细胞浸润密度之间的相关性；还评估了合并症的病史。
研究纳入了 47 名儿童（中位年龄 9.5 岁）。最常见的临床症状是腹痛（53%）和 GERD 样症状（26%）。最常见的宏观变化是白色斑块和渗出物（47%）和皱襞（34%）。28%的儿童食管外观正常。估计嗜酸性粒细胞中位数为 45 个/hpf（IQR：30-60），嗜酸性粒细胞浸润密度与临床症状或内镜特征之间无显著差异。此外，70%的儿童有过敏病史，年龄较大的儿童（>3 岁）比年龄较小的儿童更常患有花粉过敏（p<0.05）。
新诊断的嗜酸细胞性食管炎儿童的食管嗜酸性粒细胞密度与症状或内镜表现无关。
