接受治疗的韦格纳肉芽肿患者发生Ph染色体易位的继发性急性髓细胞白血病

Secondary acute myeloblastic leukemia with a Ph translocation in a treated Wegener's granulomatosis.

作者信息

Ohyashiki K, Kocova M, Ryan D H, Rowe J M, Sandberg A A

出版信息

Cancer Genet Cytogenet. 1986 Jan 15;19(3-4):331-3. doi: 10.1016/0165-4608(86)90062-2.

Abstract

Ph-positive acute myeloblastic leukemia (AML) developing in a treated case of Wegener's granulomatosis is reported. The patient was a 70-year-old white male who received cyclophosphamide (150 mg/day) starting in July 1978; in May 1984 the patient was diagnosed as having AML, following a diagnosis of myelodysplastic syndrome lasting 3 months. Cytogenetic study of bone marrow cells at the diagnosis of the myelodysplastic syndrome revealed a standard Ph translocation in addition to numerical chromosome changes [i.e., 45,XY, -5, -7, -8, +19, +mar/45,XY, -5, -7, -8, +19, +mar,t(9;22)(q34;q11]). The events in this case suggest a strong possibility of the Ph-positive AML being a secondary disease related to prior cyclophosphamide therapy.

摘要

本文报道了1例在韦格纳肉芽肿病治疗过程中发生的Ph阳性急性髓细胞白血病（AML）。患者为一名70岁白人男性，自1978年7月起接受环磷酰胺治疗（150毫克/天）；1984年5月，在诊断为骨髓增生异常综合征3个月后，该患者被诊断为AML。在诊断骨髓增生异常综合征时对骨髓细胞进行的细胞遗传学研究显示，除了染色体数目改变外，还存在标准的Ph易位[即45,XY, -5, -7, -8, +19, +mar/45,XY, -5, -7, -8, +19, +mar,t(9;22)(q34;q11)]。该病例中的情况提示，Ph阳性AML极有可能是一种与先前环磷酰胺治疗相关的继发性疾病。