Vrije Universiteit Brussel (VUB), Skin Immunology & Immune Tolerance (SKIN) Research Group, Brussels, Belgium.
Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Dermatology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Allergy. 2022 Mar;77(3):827-842. doi: 10.1111/all.15104. Epub 2021 Oct 6.
T lymphocytes (T cells) are major players of the adaptive immune response. Naive T cells are primed in the presence of cytokines, leading to polarization into distinct T-cell subsets with specific functions. These subsets are classified based on their T-cell receptor profile, expression of transcription factors, surface cytokine and chemokine receptors, and their cytokine production, which together determine their specific function. This review provides an overview of the various T-cell subsets and their function in several inflammatory skin disorders ranging from allergic inflammation to skin tumors. Moreover, we highlight similarities of T-cell responses across different skin disorders, demonstrating the presence of similar and opposing functions for the different T-cell subsets. Finally, we discuss the effects of currently available and promising therapeutic approaches to harness T cells in inflammatory skin diseases for which efficacy next to unwanted side effects provide new insights into the pathophysiology of skin disorders.
T 淋巴细胞（T 细胞）是适应性免疫反应的主要参与者。在细胞因子的存在下，初始 T 细胞被激活，导致其极化成为具有特定功能的不同 T 细胞亚群。这些亚群根据其 T 细胞受体谱、转录因子表达、表面细胞因子和趋化因子受体以及细胞因子的产生来分类，这些共同决定了它们的特定功能。这篇综述概述了各种 T 细胞亚群及其在从过敏炎症到皮肤肿瘤等多种炎症性皮肤疾病中的功能。此外，我们强调了 T 细胞反应在不同皮肤疾病中的相似性，表明不同 T 细胞亚群具有相似和相反的功能。最后，我们讨论了目前可用的和有前途的治疗方法，以利用 T 细胞治疗炎症性皮肤疾病，这些方法的疗效和不良反应为皮肤疾病的病理生理学提供了新的见解。
