Williams R M
Histopathology. 1979 Jan;3(1):19-30. doi: 10.1111/j.1365-2559.1979.tb02978.x.
An ovarian and rectal carcinoid within the same person is described. The ovarian carcinoid is non-argentaffinic with typical regular granules. The rectal tumour consists of two types of APUD cells, some argentaffinic and diazo-positive, whilst others are non-argyrophilic. These features are mirrored ultrastructurally, some cells containing the large pleomorphic argentaffinic granules while others have smaller regular granules. In addition, focal aggregates of microfilaments were found in both tumour types. These findings are discussed in terms of the APUD concept. The similarities of the APUD tumour cells to D1 APUD cells of the duodenum is highlighted, and an alternative explanation for their derivation is proposed.
本文描述了同一患者体内同时出现的卵巢类癌和直肠类癌。卵巢类癌为非嗜银性，具有典型的规则颗粒。直肠肿瘤由两种APUD细胞组成，一些细胞嗜银且重氮反应阳性，而另一些则为非嗜银性。这些特征在超微结构上也有体现，一些细胞含有大的多形性嗜银颗粒，而另一些则有较小的规则颗粒。此外，在两种肿瘤类型中均发现了微丝的局灶性聚集。根据APUD概念对这些发现进行了讨论。强调了APUD肿瘤细胞与十二指肠D1 APUD细胞的相似性，并提出了其来源的另一种解释。
