Department of Psychology, University of Toronto, Toronto, ON, Canada.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim 68159, Germany.
Neuroimage. 2021 Dec 1;244:118587. doi: 10.1016/j.neuroimage.2021.118587. Epub 2021 Sep 21.
The ability to extract cues from faces is fundamental for social animals, including humans. An individual's profile of functional connectivity across a face network can be shaped by common organizing principles, stable individual traits, and time-varying mental states. In the present study, we used data obtained with functional magnetic resonance imaging in two cohorts, IMAGEN (N = 534) and ALSPAC (N = 465), to investigate - both at group and individual levels - the consistency of the regional profile of functional connectivity across populations (IMAGEN, ALSPAC) and time (Visits 1 to 3 in IMAGEN; age 14 to 22 years). At the group level, we found a robust canonical profile of connectivity both across populations and time. At the individual level, connectivity profiles deviated from the canonical profile, and the magnitude of this deviation related to the presence of psychopathology. These findings suggest that the brain processes faces in a highly stereotypical manner, and that the deviations from this normative pattern may be related to the risk of mental illness.
从面部提取线索的能力对于包括人类在内的社交动物来说是基本的。个体在面部网络中的功能连接模式可以受到共同的组织原则、稳定的个体特征和随时间变化的心理状态的影响。在本研究中，我们使用功能磁共振成像在两个队列（IMAGEN[N=534]和ALSPAC[N=465]）中的数据，从群体和个体两个层面上，研究了功能连接模式在人群（IMAGEN，ALSPAC）和时间（IMAGEN 的访问 1 到 3；年龄 14 到 22 岁）上的一致性。在群体水平上，我们发现了一种跨越人群和时间的稳健的典型连接模式。在个体水平上，连接模式与典型模式存在偏差，这种偏差的程度与精神病理学的存在有关。这些发现表明，大脑对面部的处理方式非常刻板，而这种偏离正常模式的情况可能与精神疾病的风险有关。
