Pagano L, Marra R, De Stefano V, Di Donfrancesco A, Leone G
Minerva Med. 1986 Jan 14;77(1-2):13-7.
Neurological involvement in acute myeloid leukaemia has become more common in recent years. The increase seems to be related to the longer survival rates made possible by more intensive treatment protocols. The predictive elements appear to be the tumour mass, cytomorphological variety M5, splenomegaly and serum LDH. Prophylaxis with craniospinal radiotherapy or spinal chemotherapy does not modify the course of the leukaemia or diminish the frequency of neuromeningeal complications. Six cases of AML involving the central nervous system were examined, two at onset and 4 at first relapse. Neuromeningeal complications are to be feared since they are extremely difficult to eradicate completely and the prognosis is extremely unfavourable especially if a bone marrow relapse occurs simultaneously.
近年来，急性髓系白血病的神经受累情况变得更为常见。这种增加似乎与更强化的治疗方案使生存率提高有关。预测因素似乎是肿瘤负荷、细胞形态学类型M5、脾肿大和血清乳酸脱氢酶。采用颅脊髓放疗或脊髓化疗进行预防并不能改变白血病的病程或降低神经脑膜并发症的发生率。对6例累及中枢神经系统的急性髓系白血病病例进行了检查，2例在发病时，4例在首次复发时。由于神经脑膜并发症极难完全根除，尤其是在同时发生骨髓复发的情况下预后极差，因此令人担忧。
