Haidar Mansour, Loix Melanie, Bogie Jeroen F J, Hendriks Jerome J A
Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Trends Endocrinol Metab. 2021 Nov;32(11):941-951. doi: 10.1016/j.tem.2021.08.010. Epub 2021 Sep 21.
Lipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid levels in various tissues and disease conditions. In recent years, disruption of autophagy and accumulation of LDs have been reported as pathological hallmarks in several neurodegenerative and neuroinflammatory diseases, raising the question whether lipophagy is a process that is important in the progression of these disorders. This supports the growing interest in lipid metabolism as a major player in neurodegeneration, and the emerging understanding of several neurological pathologies as not only proteinopathies but also lipidopathies. In this review we discuss the importance of lipophagy in the most common central nervous system diseases. We examine the latest evidence for the reported interplay between abnormalities in lipid accumulation and autophagy, and propose lipophagy as a potentially important mechanism in neurodegeneration.
脂质自噬是通过自噬选择性降解脂滴（LDs）的过程。多项研究强调了脂质自噬在调节各种组织和疾病状态下细胞脂质水平方面的重要性。近年来，自噬功能障碍和脂滴积累被报道为几种神经退行性疾病和神经炎症性疾病的病理特征，这引发了脂质自噬是否在这些疾病进展中起重要作用的问题。这支持了人们对脂质代谢作为神经退行性变主要参与者的兴趣日益浓厚，以及对几种神经病理学的新认识，即它们不仅是蛋白质病，也是脂质病。在本综述中，我们讨论了脂质自噬在最常见的中枢神经系统疾病中的重要性。我们研究了脂质积累异常与自噬之间相互作用的最新证据，并提出脂质自噬是神经退行性变中一个潜在的重要机制。
