Matusow R J
Oral Surg Oral Med Oral Pathol. 1986 Jan;61(1):96-104. doi: 10.1016/0030-4220(86)90210-0.
The Part 1 report revealed the microbiologic etiology and introduced the oxidation-reduction potential (Eh) as a major factor in acute cellulitis exacerbations during endodontic therapy. Facultative streptococci were the predominant group of microbes specifically isolated. This Part 2 study revealed a 9.5% incidence of cellulitis exacerbations in patients during endodontic treatment of 168 primarily intact nonvital teeth. These teeth were usually asymptomatic, manifesting radiographic periapical lesions without fistulous tracts and necrotic canals. This category of pulpal periapical inflammation is virtually the only type of tooth that is predisposed to cellulitis exacerbations. A frequency distribution of the 34 permanent teeth studied revealed a spectrum of mandibular and maxillary molars, premolars, and anterior teeth involved with the exacerbations. Sex and age did not appear to be factors. Further clinical evidence is cited, which support the concept of altering the tissue oxidation-reduction potential as the prime etiologic factor in favoring the growth of aerobic microbial pathogens.
第一部分报告揭示了微生物病因，并引入氧化还原电位（Eh）作为根管治疗期间急性蜂窝织炎加重的主要因素。兼性链球菌是特别分离出的主要微生物群。本第二部分研究揭示，在对168颗基本完整的无活力牙齿进行根管治疗期间，患者发生蜂窝织炎加重的发生率为9.5%。这些牙齿通常无症状，表现为无窦道的根尖周影像学病变和坏死根管。这种牙髓根尖周炎症类别实际上是唯一易发生蜂窝织炎加重的牙齿类型。对所研究的34颗恒牙的频率分布显示，下颌和上颌磨牙、前磨牙和前牙都有加重情况。性别和年龄似乎不是因素。文中引用了进一步的临床证据，支持将改变组织氧化还原电位作为有利于需氧微生物病原体生长的主要病因因素这一概念。
