Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, James-Franck Str. 1, 85748, Garching, Germany.
Clinic for Birds, Small Mammals, Reptiles and Omamental Fish, Centre for Clinical Veterinary Medicine, LMU Munich, 85764, Oberschleißheim, Germany.
Sci Rep. 2021 Sep 24;11(1):19021. doi: 10.1038/s41598-021-98151-0.
Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate (MSU) crystals in peripheral joints and tissue. Detection of MSU crystals is essential for definitive diagnosis, however the gold standard is an invasive process which is rarely utilized. In fact, most patients are diagnosed or even misdiagnosed based on manifested clinical signs, as indicated by the unchanged premature mortality among gout patients over the past decade, although effective treatment is now available. An alternative, non-invasive approach for the detection of MSU crystals is X-ray dark-field radiography. In our work, we demonstrate that dark-field X-ray radiography can detect naturally developed gout in animals with high diagnostic sensitivity and specificity based on the in situ measurement of MSU crystals. With the results of this study as a potential basis for further research, we believe that X-ray dark-field radiography has the potential to substantially improve gout diagnostics.
痛风是最常见的炎症性关节炎，由单钠尿酸盐 (MSU) 晶体在周围关节和组织中的沉积引起。检测 MSU 晶体对于明确诊断至关重要，但金标准是一种侵入性过程，很少被使用。事实上，大多数患者是根据临床表现进行诊断的，甚至是误诊，这表明过去十年痛风患者的过早死亡率并没有改变，尽管现在有有效的治疗方法。MSU 晶体的另一种非侵入性检测方法是 X 射线暗场射线照相术。在我们的工作中，我们证明了暗场 X 射线射线照相术可以通过原位测量 MSU 晶体，以高诊断灵敏度和特异性检测动物中自然发生的痛风。我们相信，X 射线暗场射线照相术有可能极大地改善痛风的诊断，这项研究的结果为进一步的研究提供了潜在的基础。
