Olson D M, Lye S J, Challis J R
Pediatr Res. 1986 Jan;20(1):83-6. doi: 10.1203/00006450-198601000-00023.
Maternal and fetal sheep organs were measured for their concentrations of prostaglandins (PG) E2, F2 alpha, 13,14-dihydro-15-keto PGF2 alpha (PGFM), 6-keto PGF1 alpha (hydrolysis produce of PGI2), and 6-keto PGE1 (enzymatic product of PGI2) by radioimmunoassay at day 131 of pregnancy (0.90 gestation). It was observed that the concentrations of PGFM were greater (p less than 0.01) in maternal endometrium than in any other maternal tissue or any other PG measured in endometrium. The lowest concentrations of PG in maternal tissues were in the myometrium, while PGE2 and 6-keto PGF1 alpha were present in maternal lungs in high concentrations. Fetal prostaglandin concentrations were high in the chorioallantois, fetal portion of the cotyledons and amnion, while they were very low in the kidney, liver, and lung. Fetal lung concentrations were lower than maternal lung concentrations (p less than 0.01) for all PG measured. In fetal aorta and ductus arteriosus, 6-keto PGF1 alpha concentrations were significantly greater (p less than 0.05) than all other measured PG, while in umbilical artery and vein 6-keto PGF1 alpha levels were equal to PGE2 levels. 6-Keto PGE1 concentrations were consistently among the lowest in all tissues measured. These results suggest that the endometrium may serve as a metabolic barrier to PG diffusing from the chorioallantois to the myometrium, that the capacity of pulmonary tissue to produce PG may increase with age, that the fetal membranes and cotyledons may be one major source of circulating PG in the fetus, and that 6-keto PGF1 alpha is the major metabolite of PGI2 in ovine tissues.
在妊娠第131天（妊娠0.90期），通过放射免疫分析法测定了母羊和胎羊器官中前列腺素（PG）E2、F2α、13,14-二氢-15-酮PGF2α（PGFM）、6-酮PGF1α（PGI2的水解产物）和6-酮PGE1（PGI2的酶促产物）的浓度。观察到，母羊子宫内膜中PGFM的浓度高于任何其他母羊组织或子宫内膜中测定的任何其他PG（p<0.01）。母羊组织中PG浓度最低的是子宫肌层，而PGE2和6-酮PGF1α在母羊肺中浓度较高。胎儿前列腺素浓度在绒毛膜尿囊、子叶胎儿部分和羊膜中较高，而在肾脏、肝脏和肺中则非常低。对于所有测定的PG，胎儿肺中的浓度低于母羊肺中的浓度（p<0.01）。在胎儿主动脉和动脉导管中，6-酮PGF1α的浓度显著高于所有其他测定的PG（p<0.05），而在脐动脉和静脉中，6-酮PGF1α的水平与PGE2的水平相等。6-酮PGE1的浓度在所有测定组织中一直是最低的。这些结果表明，子宫内膜可能作为PG从绒毛膜尿囊扩散到子宫肌层的代谢屏障，肺组织产生PG的能力可能随年龄增加，胎膜和子叶可能是胎儿循环中PG的一个主要来源，并且6-酮PGF1α是绵羊组织中PGI2的主要代谢产物。
