Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong 250021, China; Shandong Institute of Endocrine & Metabolic Disease, Jinan, Shandong 250062, China.
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong 250021, China; Shandong Institute of Endocrine & Metabolic Disease, Jinan, Shandong 250062, China.
Cell Metab. 2021 Oct 5;33(10):1911-1925. doi: 10.1016/j.cmet.2021.09.001. Epub 2021 Sep 24.
High levels of cholesterol are generally considered to be associated with atherosclerosis. In the past two decades, however, a number of studies have shown that excess cholesterol accumulation in various tissues and organs plays a critical role in the pathogenesis of multiple diseases. Here, we summarize the effects of excess cholesterol on disease pathogenesis, including liver diseases, diabetes, chronic kidney disease, Alzheimer's disease, osteoporosis, osteoarthritis, pituitary-thyroid axis dysfunction, immune disorders, and COVID-19, while proposing that excess cholesterol-induced toxicity is ubiquitous. We believe this concept will help broaden the appreciation of the toxic effect of excess cholesterol, and thus potentially expand the therapeutic use of cholesterol-lowering medications.
高胆固醇水平通常被认为与动脉粥样硬化有关。然而，在过去的二十年中，许多研究表明，各种组织和器官中胆固醇的过度积累在多种疾病的发病机制中起着关键作用。在这里，我们总结了过量胆固醇对疾病发病机制的影响，包括肝脏疾病、糖尿病、慢性肾脏病、阿尔茨海默病、骨质疏松症、骨关节炎、垂体-甲状腺轴功能障碍、免疫紊乱和 COVID-19，同时提出过量胆固醇诱导的毒性是普遍存在的。我们相信这个概念将有助于拓宽对过量胆固醇毒性作用的认识，从而有可能扩大降胆固醇药物的治疗用途。
