Schmidt P, Kopsa H, Balcke P, Zargornik J, Mayr W R, Wagner O, Piza F
Wien Klin Wochenschr. 1978 Mar 17;90(6):193-7.
In order to investigate the influence of pretransplant blood transfusions on renal graft survival, the results in 43 recipients with 10 or more transfusion (group A) were compared with those in 48 recipients with less than 10 or no transfusions (group B). In both groups cadaveric kidneys with mainly 3 or more mismatched histocompatibility antigens were transplanted. The incidence of preformed cytotoxic antibodies was similar in both groups (25.6% and 22.9%, respectively). The cumulative renal graft survival rate was significantly higher in the poly-transfused group: 85.6% +/- 6.1% and 73.4 +/- 7.9% after 1 and 2 years, respectively, in group A in comparison with 73.9 +/- 6.6% and 63.3 +/- 8.1% after 1 and 2 years respectively, in group B (Wilcoxon rank sum test: p less than 0.05). Severe renal rejection with a serum creatinine above 3 mg/100 ml was more frequently observed in group B than in group A. Enhancement due to blocking antibodies must be assumed as a possible explanation for the favourable effect of repeated pretransplant transfusions on graft survival rates.
为了研究移植前输血对肾移植存活的影响，将43例接受过10次或更多次输血的受者（A组）的结果与48例接受过少于10次输血或未输血的受者（B组）的结果进行了比较。两组均移植了主要有3个或更多不匹配组织相容性抗原的尸体肾。两组中预先形成的细胞毒性抗体的发生率相似（分别为25.6%和22.9%）。多次输血组的肾移植累积存活率显著更高：A组1年和2年后分别为85.6%±6.1%和73.4±7.9%，而B组1年和2年后分别为73.9±6.6%和63.3±8.1%（Wilcoxon秩和检验：p<0.05）。血清肌酐高于3mg/100ml的严重肾排斥反应在B组比在A组更常见。必须假定由封闭抗体引起的增强作用是移植前反复输血对移植物存活率产生有利影响的一种可能解释。
