Native Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn's Disease: A Comparative Animal Study.

In this study, we investigated the utility of native mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats undergoing native mapping and MTI were enrolled. The longitudinal relaxation time ( value) and normalized magnetization transfer ratio (MTR) were compared between none-to-mild and moderate-to-severe fibrotic bowel walls confirmed by pathological assessments. The results showed that the correlation between the value and fibrosis ( = 0.438, < 0.001) was lower than that between the normalized MTR and fibrosis ( = 0.623, < 0.001). Overall, the values ( = -3.066, = 0.004) and normalized MTRs ( = 0.081, < 0.001) in none-to-mild fibrotic bowel walls were lower than those in moderate-to-severe fibrotic bowel walls. The area under the curve (AUC) of the value (AUC = 0.716, = 0.004) was significantly lower than that of the normalized MTR (AUC = 0.881, < 0.001) in differentiating moderate-to-severe fibrosis from none-to-mild fibrosis ( = -2.037, = 0.042). Our results support the view that the value could be a promising imaging biomarker in grading the fibrosis severity of CD. However, the diagnostic performance of native mapping was not superior to MTI.