Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No. 1665, Kongjiang Road, Shanghai, 200092, China.
Philips Healthcare, Shanghai, 200233, China.
Eur Radiol. 2020 Jan;30(1):337-345. doi: 10.1007/s00330-019-06335-0. Epub 2019 Jul 23.
To investigate the repeatability, reproducibility, and staging and monitoring of the performance of native T1 mapping for noninvasively assessing liver fibrosis in comparison with acoustic radiation force impulse (ARFI) elastography.
The repeatability and reproducibility were explored in 8 male Sprague-Dawley rats with intraclass correlation coefficient (ICC). Different degrees of fibrosis were induced in 52 rats by carbon-tetrachloride (CCl4) insult. Another 16 rats were used to build fibrosis progression and regression models. The native T1 values and shear wave velocity (SWV) were quantified by using native T1 mapping and ARFI elastography, respectively. The METAVIR system (F0-F4) was used for the staging of fibrosis. The area under the receiver operating characteristic curve (AUC) was determined to assess the performance of quantitative parameters for staging and monitoring fibrosis.
Native T1 values shared similar good repeatability (ICC = 0.93) and reproducibility (ICC = 0.87) with SWV (ICC = 0.84-0.93). The AUC of native T1 values were 0.84, 0.84, and 0.75 for diagnosing significant fibrosis (≥ F2) and liver cirrhosis (F4) and detecting fibrosis progression, and those of SWV were 0.81, 0.86, and 0.7, respectively. No significant difference in performance was found between the two quantitative parameters (p ≥ 0.496). For detecting fibrosis regression, native T1 values had a better accuracy (AUC = 0.99) than SWV (AUC = 0.56; p = 0.002).
Native T1 mapping may be a reliable and accurate method for noninvasively assessing liver fibrosis. Compared with ARFI elastography, it provides similar good repeatability and reproducibility, a similar high accuracy for staging fibrosis, and a better accuracy for detecting fibrosis regression.
• Native T1 mapping is a valuable tool for noninvasively assessing liver fibrosis and can be measured on virtually all clinical MRI machines without additional hardware or gadolinium chelate injection. • Compared with acoustic radiation force impulse elastography, native T1 mapping yields similar good repeatability and reproducibility and a similar high accuracy for staging fibrosis. • Native T1 mapping provides a significantly better performance for detecting fibrosis regression than acoustic radiation force impulse elastography.
与声辐射力脉冲（ARFI）弹性成像相比，探讨使用 T1 自然映射技术非侵入性评估肝纤维化的重复性、可再现性以及分期和监测性能。
采用组内相关系数（ICC）评估 8 只雄性 Sprague-Dawley 大鼠的重复性和可再现性。采用四氯化碳（CCl4）损伤在 52 只大鼠中诱导不同程度的纤维化。另外 16 只大鼠用于构建纤维化进展和消退模型。通过 T1 自然映射和 ARFI 弹性成像分别定量测量 T1 自然值和剪切波速度（SWV）。采用 METAVIR 系统（F0-F4）对纤维化进行分期。确定受试者工作特征曲线下面积（AUC）以评估定量参数对分期和监测纤维化的性能。
T1 自然值与 SWV（ICC=0.84-0.93）具有相似的良好重复性（ICC=0.93）和可再现性（ICC=0.87）。T1 自然值诊断显著纤维化（≥F2）和肝硬化（F4）和检测纤维化进展的 AUC 分别为 0.84、0.84 和 0.75，SWV 的 AUC 分别为 0.81、0.86 和 0.7。两种定量参数的性能无显著差异（p≥0.496）。对于检测纤维化消退，T1 自然值的准确性（AUC=0.99）优于 SWV（AUC=0.56；p=0.002）。
T1 自然映射可能是一种可靠且准确的方法，可用于非侵入性评估肝纤维化。与 ARFI 弹性成像相比，它提供了相似的良好重复性和可再现性、相似的高纤维化分期准确性以及更好的纤维化消退检测准确性。
T1 自然映射是一种评估肝纤维化的有价值的工具，可在几乎所有临床 MRI 机器上进行测量，无需额外的硬件或钆螯合物注射。
与声辐射力脉冲弹性成像相比，T1 自然映射具有相似的良好重复性和可再现性，以及相似的高纤维化分期准确性。
T1 自然映射在检测纤维化消退方面的性能明显优于声辐射力脉冲弹性成像。
