Chen Mingming, Yang Shilei, Wu Yu, Zhao Zirui, Zhai Xiaohan, Dong Deshi
Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, 222, Zhongshan Road, Xigang District, 116011, Dalian, China.
Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Cancer Cell Int. 2021 Sep 25;21(1):513. doi: 10.1186/s12935-021-02203-4.
As the life expectancy of the population increases worldwide, cancer is becoming a substantial public health problem. Considering its recurrence and mortality rates, most cancer cases are difficult to cure. In recent decades, a large number of studies have been carried out on different cancer types; unfortunately, tumor incidence and mortality have not been effectively improved. At present, early diagnostic biomarkers and accurate therapeutic strategies for cancer are lacking. High temperature requirement A1 (HtrA1) is a trypsin-fold serine protease that is also a chymotrypsin-like protease family member originally discovered in bacteria and later discovered in mammalian systems. HtrA1 gene expression is decreased in diverse cancers, and it may play a role as a tumor suppressor for promoting the death of tumor cells. This work aimed to examine the role of HtrA1 as a cell type-specific diagnostic biomarker or as an internal and external regulatory factor of diverse cancers. The findings of this study will facilitate the development of HtrA1 as a therapeutic target.
随着全球人口预期寿命的增加，癌症正成为一个重大的公共卫生问题。考虑到其复发率和死亡率，大多数癌症病例难以治愈。近几十年来，针对不同癌症类型开展了大量研究；遗憾的是，肿瘤发病率和死亡率并未得到有效改善。目前，缺乏癌症的早期诊断生物标志物和准确的治疗策略。高温需求A1（HtrA1）是一种胰蛋白酶样丝氨酸蛋白酶，也是一种胰凝乳蛋白酶样蛋白酶家族成员，最初在细菌中发现，后来在哺乳动物系统中发现。HtrA1基因在多种癌症中的表达降低，它可能作为一种肿瘤抑制因子，促进肿瘤细胞死亡。这项工作旨在研究HtrA1作为细胞类型特异性诊断生物标志物或作为多种癌症的内部和外部调节因子的作用。本研究结果将有助于将HtrA1开发为治疗靶点。
