Department of BioMechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Mekelweg 2, Delft 2628 CD, the Netherlands.
Department of Medical Imaging, Radboud Institute for Health Sciences, Radboud university Medical Center, Geert Grooteplein Zuid 10, Nijmegen 6525 GA, the Netherlands.
Med Eng Phys. 2021 Oct;96:13-21. doi: 10.1016/j.medengphy.2021.07.009. Epub 2021 Aug 12.
Microbrachytherapy with radioactive holmium-166 (Ho) microspheres (MS) has the potential to be an effective treatment method for brain malignancies. Direct intratumoural delivery of Ho-MS and dose coverage of the whole tumour are crucial requirements. However, currently no dedicated instruments for controlled intratumoural delivery exist. This study presents an administration device that facilitates this novel magnetic resonance imaging (MRI) -guided intervention. The bioceramic alumina oxide cannula creates a straight channel for a superelastic nitinol precurved stylet to control spatial deposition of Ho-MS. End-point accuracy of the stylet was measured during insertions in phantoms. Imaging tests were performed in a 3 Tesla MRI-scanner to quantify instrument-induced artefacts. Additionally, the feasibility of non-radioactive holmium-165 (Ho)-MS delivery with the administration device was evaluated in a brain tumour simulant. Absolute stylet tip error was 0.88 ± 0.61 mm, instrument distortion in MRI depended on needle material and orientation and dose delivery of Ho-MS in a brain tumour phantom was possible. This study shows that the administration device can accurately place the stylet for injection of Ho-MS and that visualization can be performed with MRI.
放射性钬-166（Ho）微球（MS）的微束疗法具有成为治疗脑恶性肿瘤的有效方法的潜力。直接向肿瘤内输送 Ho-MS 和覆盖整个肿瘤的剂量是至关重要的要求。然而，目前不存在用于控制肿瘤内输送的专用仪器。本研究提出了一种给药装置，可促进这种新的磁共振成像（MRI）引导的干预。生物陶瓷氧化铝管为超弹性镍钛诺预弯曲引导丝创建了一个直通道，以控制 Ho-MS 的空间沉积。在模拟物中插入时测量了引导丝的终点精度。在 3 Tesla MRI 扫描仪中进行了成像测试，以量化器械引起的伪影。此外，还评估了给药装置在脑肿瘤模拟物中输送非放射性钬-165（Ho）-MS 的可行性。绝对引导丝尖端误差为 0.88 ± 0.61mm，MRI 中的器械变形取决于针的材料和方向，并且可以在脑肿瘤模拟物中进行 Ho-MS 的剂量输送。本研究表明，给药装置可以准确地放置用于注射 Ho-MS 的引导丝，并且可以使用 MRI 进行可视化。
