Sistac Ballarín J M, Solé Guixes J, Groizard Botella M J, Sistac Palacín J M
Servicio de Anestesiología y Reanimación, Hospital Universitario Arnau de Vilanova, Facultad de Medicina, Universitat de Lleida, Lleida, España.
Servicio de Anestesiología y Reanimación, Hospital Universitario Arnau de Vilanova, Lleida, España.
Rev Esp Anestesiol Reanim (Engl Ed). 2021 Sep 23. doi: 10.1016/j.redar.2021.03.008.
To assess the mean time to hypnosis, hemodynamic stability, and incidence of complications associated with the administration of 70mg/kg oral chloral hydrate in children scheduled for magnetic resonance imaging (MRI).
Prospective study conducted from January 2000 to January 2020 in which 3,132 patients aged between one day and 5 years underwent MRI under anaesthesia in an outpatient setting. The study population was divided into 4 subgroups: A) aged between one and 30 days; B) aged between one month and one year; C) aged between one and 3 years, and D) aged between 3 and 5 years. Study variables were: sex, age, type of examination, mean imaging time, mean time to awakening, heart rate before and after MRI, SatO, and incidence of complications such as respiratory depression (SatO below 90%), agitation during the MRI or on awakening (intense crying lasting more than 2min), prolonged sedation measured on the Steward scale, and nausea and/or vomiting during the MRI, on awakening, or at home.
No notable hemodynamic alterations were observed. The incidence of desaturation was 0.41%, awakening during the test was 0.16%, prolonged sedation was 1.08%, and agitated awakening was 1.46%. Nausea and vomiting at the end of the test had an incidence of 0.73%. The P value in all cases was<.05%.
Chloral hydrate at a dose of 70mg/kg continues to be suitable in sedation lasting no more than one hour for non-invasive procedures in children, and is associated with adequate haemodynamic stability with practically no side effects.
评估计划进行磁共振成像（MRI）检查的儿童口服70mg/kg水合氯醛后达到催眠状态的平均时间、血流动力学稳定性及并发症发生率。
2000年1月至2020年1月进行的前瞻性研究，3132例年龄在1天至5岁之间的患者在门诊接受麻醉下的MRI检查。研究人群分为4个亚组：A）1至30天；B）1个月至1岁；C）1至3岁；D）3至5岁。研究变量包括：性别、年龄、检查类型、平均成像时间、平均苏醒时间、MRI前后的心率、血氧饱和度（SatO），以及并发症发生率，如呼吸抑制（SatO低于90%）、MRI期间或苏醒时躁动（剧烈哭闹持续超过2分钟）、根据Steward量表测量的镇静时间延长，以及MRI期间、苏醒时或在家中出现的恶心和/或呕吐。
未观察到明显的血流动力学改变。血氧饱和度降低的发生率为0.41%，检查期间苏醒的发生率为0.16%，镇静时间延长的发生率为1.08%，躁动性苏醒的发生率为1.46%。检查结束时恶心和呕吐的发生率为0.73%。所有病例的P值均<0.05%。
70mg/kg剂量的水合氯醛仍然适用于儿童不超过1小时的非侵入性检查镇静，并且与足够的血流动力学稳定性相关，几乎没有副作用。
