Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Trends Neurosci. 2021 Nov;44(11):915-924. doi: 10.1016/j.tins.2021.08.006. Epub 2021 Sep 23.
A pericellular basket is a presynaptic configuration of numerous axonal boutons outlining a target neuron soma and its proximal dendrites. Recent studies show neurochemical diversity of pericellular baskets and suggest that neurotransmitter usage together with the dense, soma-proximal boutons may permit strong input effects on different timescales. Here we review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. As an example, we highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei. We propose that pericellular baskets represent convergence sites of competition or facilitation between neurotransmitter systems on downstream circuitry, especially in limbic brain regions, where pericellular baskets are widespread. Study of these baskets may enhance our understanding of monoamine regulation of memory, social behavior, and brain oscillations.
细胞周筐是一种突触前结构，由大量轴突末梢围绕靶神经元胞体及其近端树突形成。最近的研究表明细胞周筐具有神经化学多样性，并提示神经递质的使用以及密集的胞体近端末梢可能允许不同时间尺度上的强输入效应。本文综述了细胞周筐的发育、分布、神经化学表型和可能的功能。作为一个例子，我们强调了由某些 5-羟色胺能中缝核的 Pet1/Fev 神经元的投射形成的细胞周筐。我们提出，细胞周筐代表了下游回路中神经递质系统之间竞争或易化的汇聚位点，特别是在广泛存在细胞周筐的边缘脑区。对这些细胞周筐的研究可以增进我们对单胺类物质调节记忆、社会行为和脑振荡的理解。
