动脉粥样硬化中血管平滑肌细胞凋亡的研究进展。
Research progress in apoptosis of vascular smooth muscle cells in atherosclerosis.
机构信息
Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University; Third People's Hospital of Chengdu, Chengdu 610031, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Aug 28;46(8):872-876. doi: 10.11817/j.issn.1672-7347.2021.200858.
Abstract
Vascular smooth muscle cell (VSMC) is one of the main cell types in blood vessel wall, and the VSMC apoptosis is involved in the development of atherosclerosis (AS). In early AS, the apoptosis of VSMC is regarded as a compensatory mechanism for neointimal hyperplasia and lumen stenosis. However, this process will also accelerate the rupture of atherosclerotic plaques, resulting in serious cardiovascular complications. More studies on the related genes, RNA, and inducing factors of VSMCs apoptosis in occurrence and development of AS can provide scientific strategies for prevention and treatment of AS in different periods.
摘要
血管平滑肌细胞（VSMC）是血管壁的主要细胞类型之一，VSMC 凋亡参与动脉粥样硬化（AS）的发生发展。在 AS 的早期，VSMC 的凋亡被认为是向心性内膜增生和管腔狭窄的代偿机制。然而，这一过程也会加速粥样斑块的破裂，导致严重的心血管并发症。更多关于 AS 发生发展过程中 VSMC 凋亡的相关基因、RNA 和诱导因子的研究，可以为不同时期 AS 的防治提供科学策略。
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