Wan Hong, Xu Xiaojun, Yang Xiaowei, Li Angqing, Ma Xiaopeng, Xu Aman, Yuan Xiao, Wang Wenbin, Guo Tao, Luo Guangtao, He Xiaobo, Li Wang, Wang Zhaorui, Sun Qiang, Pei Jing, Guo Yongzhen, Zhu Yong
Department of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Pharmacol. 2021 Sep 10;12:720886. doi: 10.3389/fphar.2021.720886. eCollection 2021.
Shiyiwei Shenqi Tablet (SSTs) has been widely used for treatment of different types of cancer including breast cancer. SST has drawn more and more interest due to the low rate of side effects. The aim of this study was to investigate the metabolites in serums of breast cancer patients who received base-line chemotherapy only or combination treatment with SST. An untargeted metabolomics method was developed to investigate the alteration of metabolism in patients' serums using ultra-high-performance liquid chromatography/Q-exactive Orbitrap mass spectrometry. The patients were separated based on the metabolomics data, and further analyses showed that SST treatment can affect the metabolism of glucose, fatty acid, bile acid and amino acid. In particular, SST treatment significantly reduced some short peptides which are potential tumor neoantigens. This study may provide novel insights into the mechanism underlying interaction between SST and base-line chemotherapy in terms of affecting metabolic pathways and thereby changing metabolic products, which might shed new light for clinical medication.
十一味参芪片（SSTs）已被广泛用于治疗包括乳腺癌在内的不同类型癌症。由于副作用发生率低，SST越来越受到关注。本研究的目的是调查仅接受基线化疗或联合SST治疗的乳腺癌患者血清中的代谢物。开发了一种非靶向代谢组学方法，使用超高效液相色谱/Q-Exactive轨道阱质谱法研究患者血清中的代谢变化。根据代谢组学数据对患者进行分类，进一步分析表明SST治疗可影响葡萄糖、脂肪酸、胆汁酸和氨基酸的代谢。特别是，SST治疗显著减少了一些潜在肿瘤新抗原的短肽。本研究可能为SST与基线化疗在影响代谢途径从而改变代谢产物方面的相互作用机制提供新的见解，这可能为临床用药提供新的思路。
